ArticleImmunity2008
Apoptosis regulators Bim and Fas function concurrently to control autoimmunity and CD8+ T cell contraction.
Article in Immunity, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
118 citing papers in PubMed, 191 citations in OpenAlex.
- Limited roles of the miR-17-92 cluster in the regulation of T-cell apoptosis.The FEBS journal · 2026Article
- High levels of circulating miR-19a-3p in patients with metastatic HER2 + breast cancer are associated with a favorable prognosis and anti-tumor immune responses.Breast cancer research : BCR · 2026Article
- Review
- Waste management and cell death in T cells.Nature cell biology · 2024Article
- Autocrine VEGF-B signaling maintains lipid synthesis and mitochondrial fitness to support T cell immune responses.The Journal of clinical investigation · 2024Article
- Induction of immortal-like and functional CAR T cells by defined factors.The Journal of experimental medicine · 2024Article
- CD95/Fas ligand induced toxicity.Biochemical Society transactions · 2023Article
- Metabolism along the life journey of T cells.Life metabolism · 2023Article
- Molecular and temporal control of restimulation-induced cell death (RICD) in T lymphocytes.Frontiers in cell death · 2023Article
- Immune phenotypes that are associated with subsequent COVID-19 severity inferred from post-recovery samples.Nature communications · 2022Article
- Regulation of T Cells in Cancer by Nitric Oxide.Cells · 2021Review
- TRAF2 regulates T cell immunity by maintaining a Tpl2-ERK survival signaling axis in effector and memory CD8 T cells.Cellular & molecular immunology · 2021Article
- Severely ill COVID-19 patients display impaired exhaustion features in SARS-CoV-2-reactive CD8Science immunology · 2021Article
- FOXP3 protects conventional human T cells from premature restimulation-induced cell death.Cellular & molecular immunology · 2021Article
- Severely ill COVID-19 patients display augmented functional properties in SARS-CoV-2-reactive CD8bioRxiv : the preprint server for biology · 2020Article
- T-cell receptor signal strength and epigenetic control of Bim predict memory CD8Cell death and differentiation · 2020Article
- Understanding the role of key amino acids in regulation of proline dehydrogenase/proline oxidase (prodh/pox)-dependent apoptosis/autophagy as an approach to targeted cancer therapy.Molecular and cellular biochemistry · 2020Review
- Metabolic Reprogramming in CD8Frontiers in immunology · 2020Review
- Aging boosts antiviral CD8+T cell memory through improved engagement of diversified recall response determinants.PLoS pathogens · 2019Article
- Caspase-8-dependent control of NK- and T cell responses during cytomegalovirus infection.Medical microbiology and immunology · 2019Review
58 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on byFas Bim boom!2008
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Throughout most of adult life, lymphocyte number remains constant because of a balance of proliferation and apoptosis. Mutation of Bim, a proapoptotic protein in the intrinsic death pathway, or Fas, a tumor necrosis factor receptor (TNFR) superfamily member of the extrinsic pathway, results in late-onset autoimmunity and increased antigen-specific CD8(+) T cell responses during viral infection. However, virus-specific immune responses eventually return to amounts comparable to those for nonmutant mice. Here, we show that loss of both Bim and Fas function resulted in a synergistic disruption of lymphoid homeostasis, rapid-onset autoimmunity, and organ-specific blocks on contraction of antiviral immune responses. When lymphocytic choriomeningitis virus (LCMV)-specific immune responses were quantitated, double-mutant mice had 100-fold more antigen-specific memory CD8(+) T cells in their lymph nodes than wild-type mice. Our results demonstrate that multiple death pathways function concurrently to prevent autoimmunity and downsize T cell responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.