Evidence map›Paper›PMID 18275615›Full record

ArticleCost effectiveness and resource allocation : C/E2008

The cost of antiretroviral therapy in Haiti.

Serena P Koenig, Cynthia Riviere, Paul Leger, Patrice Severe, Sidney Atwood, Daniel W Fitzgerald, Jean W Pape, Bruce R Schackman

Abstract read
In one paragraph

Article in Cost effectiveness and resource allocation : C/E, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  12. Clinical impact and cost of monitoring for asymptomatic laboratory abnormalities among patients receiving antiretroviral therapy in a resource-poor setting.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2010
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Serena P KoenigDivision of Social Medicine and Health Inequalities, Brigham and Women's Hospital, Boston, MA 02115, USA. skoenig@partners.org
Cynthia Riviere
Paul Leger
Patrice Severe
Sidney Atwood
Daniel W Fitzgerald
Jean W Pape
Bruce R Schackman

Funding

TUBERCULOSIS INTERNATIONAL TRAINING AND RESEARCH PROGRAMD43TW000018 · FIC · WEILL MEDICAL COLL OF CORNELL UNIV · PI JOHNSON, WARREN DOUGLAS · 1988 to 2012
$16.1M
Health Outcomes/Cost of Early vs Delayed ART in HaitiK01TW007142 · FIC · BRIGHAM AND WOMEN'S HOSPITAL · PI KOENIG, SERENA PATRICIA · 2004 to 2011
$878k
Informed Consent in Developing Country ResearchK01TW000002 · FIC · WEILL MEDICAL COLLEGE OF CORNELL UNIV · PI FITZGERALD, DANIEL W · 1999 to 2004
$666k
FIC NIH HHS D43 TW000018FIC NIH HHS K01 TW000002FIC NIH HHS K01 TW007142
6 · The paper itself

Abstract

backgroundWe determined direct medical costs, overhead costs, societal costs, and personnel requirements for the provision of antiretroviral therapy (ART) to patients with AIDS in Haiti.

methodsWe examined data from 218 treatment-naïve adults who were consecutively initiated on ART at the GHESKIO Center in Port-au-Prince, Haiti between December 23, 2003 and May 20, 2004 and calculated costs and personnel requirements for the first year of ART.

resultsThe mean total cost of treatment per patient was $US 982 including $US 846 in direct costs, $US 114 for overhead, and $US 22 for societal costs. The direct cost per patient included generic ART medications $US 355, lab tests $US 130, nutrition $US 117, hospitalizations $US 62, pre-ART evaluation $US 58, labor $US 51, non-ART medications $US 39, outside referrals $US 31, and telephone cards for patient retention $US 3. Higher treatment costs were associated with hospitalization, change in ART regimen, TB treatment, and survival for one year. We estimate that 1.5 doctors and 2.5 nurses are required to treat 1000 patients in the first year after initiating ART.

conclusionInitial ART treatment in Haiti costs approximately $US 1,000 per patient per year. With generic first-line antiretroviral drugs, only 36% of the cost is for medications. Patients who change regimens are significantly more expensive to treat, highlighting the need for less-expensive second-line drugs. There may be sufficient health care personnel to treat all HIV-infected patients in urban areas of Haiti, but not in rural areas. New models of HIV care are needed for rural areas using assistant medical officers and community health workers.

Identifiers

PMID18275615
PMCPMC2276481

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.