ArticleThe Journal of infectious diseases2008
Molecular and bioinformatic evidence of hepatitis C virus evolution in brain.
Article in The Journal of infectious diseases, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 90 citations in OpenAlex.
- Depressive symptoms in chronic hepatitis C are associated with plasma apolipoprotein E deficiency.Metabolic brain disease · 2014Trial
- Effects of active HCV replication on neurologic status in HIV RNA virally suppressed patients.Neurology · 2009Trial
- Viruses and psychiatric disorders: We have not crossed the borderline from hypothesis to proof yet (Review).Molecular medicine reports · 2025Review
- Chronic Hepatitis C Virus Infection, Extrahepatic Disease and the Impact of New Direct-Acting Antivirals.Pathogens (Basel, Switzerland) · 2024Review
- Avenues within the gut-liver-brain axis linking chronic liver disease and symptoms.Frontiers in neuroscience · 2023Review
- Role of hepatitis c virus in hepatocellular carcinoma and neurological disorders: an overview.Frontiers in oncology · 2022Review
- Hepatitis C Virus-Related Central and Peripheral Nervous System Disorders.Brain sciences · 2021Review
- Review
- The Many Difficulties and Subtleties in the Cognitive Assessment of Chronic Hepatitis C Infection.International journal of hepatology · 2020Review
- Review
- Brain magnetic resonance spectroscopy and cognitive impairment in chronic hepatitis C patients.The Egyptian journal of neurology, psychiatry and neurosurgery · 2018Article
- Hepatitis C virus infection, and neurological and psychiatric disorders - A review.Journal of advanced research · 2017Review
- Mice Expressing Minimally Humanized CD81 and Occludin Genes Support Hepatitis C Virus Uptake In Vivo.Journal of virology · 2017Article
- Hepatocarcinogenesis associated with hepatitis B, delta and C viruses.Current opinion in virology · 2016Review
- Deep sequencing of hepatitis C virus reveals genetic compartmentalization in cerebrospinal fluid from cognitively impaired patients.Liver international : official journal of the International Association for the Study of the Liver · 2016Article
- Hepatitis C virus and neurological damage.World journal of hepatology · 2016Review
- Reduced cerebral cortical thickness in Non-cirrhotic patients with hepatitis C.Metabolic brain disease · 2016Article
- Diminished viral replication and compartmentalization of hepatitis C virus in hepatocellular carcinoma tissue.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Rapid Regulation of Depression-Associated Genes in a New Mouse Model Mimicking Interferon-α-Related Depression in Hepatitis C Virus Infection.Molecular neurobiology · 2015Article
- Chronic hepatitis C virus infection and neurological and psychiatric disorders: an overview.World journal of gastroenterology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundNeurocognitive deficits in patients with hepatitis C virus (HCV) infection prompted a search for HCV in brain.
resultsHCV was present in the brains of 7 (54%) of 13 patients with viremia, as determined by 5' UTR and E1 (envelope 1) gene analysis. Brain HCV RNA consensus sequences differed from those in plasma and liver in 4 (57%) of 7 patients. The quality of HCV RNA from postmortem brain and liver was assessed and demonstrated to be suitable for sequence analysis. Quasispecies analysis revealed that several mutations present in clones from >1 brain region were absent in clones from liver and plasma. Brain-specific mutations defined several families of related sequences. The patterns of brain-specific mutations in these families were consistent with the evolution of HCV RNA from a common ancestor. Single-nucleotide-polymorphism analysis confirmed that a prominent brain-specific mutation constituted approximately 10% of HCV RNA in cerebellum and medulla but that this mutation was undetectable in the liver and plasma of the same patient.
conclusionsThis study introduces novel methods for assessing RNA from postmortem samples. It increases the reported cases of HCV in the brain, provides the first E1 sequences from the brain, and contributes to the growing evidence that HCV replicates and evolves within the brain.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.