ArticleNeurochemical research2008
Novel form of phosphate activated glutaminase in cultured astrocytes and human neuroblastoma cells, PAG in brain pathology and localization in the mitochondria.
Article in Neurochemical research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Review
- N-Acetylneuraminic acid triggers endothelial pyroptosis and promotes atherosclerosis progression via GLS2-mediated glutaminolysis pathway.Cell death discovery · 2024Article
- GAPDH in neuroblastoma: Functions in metabolism and survival.Frontiers in oncology · 2022Review
- Cerebral edema and liver disease: Classic perspectives and contemporary hypotheses on mechanism.Neuroscience letters · 2020Review
- Targeting Glutamine Induces Apoptosis: A Cancer Therapy Approach.International journal of molecular sciences · 2015Review
- Glutamate and GABA-metabolizing enzymes in post-mortem cerebellum in Alzheimer's disease: phosphate-activated glutaminase and glutamic acid decarboxylase.Cerebellum (London, England) · 2014Article
- Novel treatment with neuroprotective and antiviral properties against a neuroinvasive human respiratory virus.Journal of virology · 2014Article
- Glutamine in the pathogenesis of hepatic encephalopathy: the trojan horse hypothesis revisited.Neurochemical research · 2014Review
- Oncogenes and tumor suppressors regulate glutamine metabolism in cancer cells.Journal of cancer prevention · 2013Review
- Astrocytic Control of Biosynthesis and Turnover of the Neurotransmitters Glutamate and GABA.Frontiers in endocrinology · 2013Article
- HIV-1, methamphetamine and astrocyte glutamate regulation: combined excitotoxic implications for neuro-AIDS.Current HIV research · 2012Review
- Astrocyte glutamine synthetase: importance in hyperammonemic syndromes and potential target for therapy.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2010Review
- Kinetics of a novel isoform of phosphate activated glutaminase (PAG) in SH-SY5Y neuroblastoma cells.Neurochemical research · 2010Article
- Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A novel form of phosphate activated glutaminase (PAG), catalyzing the synthesis of glutamate from glutamine, has been detected in cultured astrocytes and SH-SY5Y neuroblastoma cells. This enzyme form is different from that of the kidney and liver isozymes. In these cells we found high enzyme activity, but no or very weak immunoreactivity against the kidney type of PAG, and no immunoreactivity against the liver type. PAG was also investigated in brain under pathological conditions. In patients with Down's syndrome the immunoreactivity in the frontoparietal cortex was significantly reduced. The findings leading to our conclusion of a functionally active PAG on the outer face of the inner mitochondrial membrane are discussed, and a model is presented.
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