ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2008
The validity of generic and condition-specific preference-based instruments: the ability to discriminate asthma control status.
Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Health-related quality of life in adult patients with asthma according to asthma control and severity: A systematic review and meta-analysis.Frontiers in pharmacology · 2022Pooled it
- Clinical, economic, and humanistic burden of asthma in Canada: a systematic review.BMC pulmonary medicine · 2013Pooled it
- How does the EQ-5D-5L perform in asthma patients compared with an asthma-specific quality of life questionnaire?BMC pulmonary medicine · 2020Trial
- The added effect of comorbidity on health-related quality of life in patients with asthma.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2015Trial
- Cost-effectiveness of Internet-based self-management compared with usual care in asthma.PloS one · 2011Trial
- Are EQ-5D-Y-3L and EQ-5D-Y-5L Useful Tools to Assess Health Outcomes in Children With Asthma? An Analysis of Child and Parental Carer Reporting.Pediatric pulmonology · 2025Article
- Measurement properties of the EQ-5D-Y administered through a smartphone app in children with asthma: a longitudinal questionnaire study.Health and quality of life outcomes · 2022Article
- The construct validity and responsiveness of the EQ-5D-5L, AQL-5D and a bespoke TTO in acute asthmatics.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2020Article
- Effect of asthma control on general health-related quality of life in patients diagnosed with adult-onset asthma.Scientific reports · 2019Article
- Article
- EuroQol (EQ-5D-5L) Validity in Assessing the Quality of Life in Adults With Asthma: Cross-Sectional Study.Journal of medical Internet research · 2019Article
- Is the EQ-5D fit for purpose in asthma? Acceptability and content validity from the patient perspective.Health and quality of life outcomes · 2018Article
- A comparison of the responsiveness of EQ-5D-5L and the QOLIE-31P and mapping of QOLIE-31P to EQ-5D-5L in epilepsy.The European journal of health economics : HEPAC : health economics in prevention and care · 2018Article
- Impact of asthma on women and men: Comparison with the general population using the EQ-5D-5L questionnaire.PloS one · 2018Article
- The Role of Condition-Specific Preference-Based Measures in Health Technology Assessment.PharmacoEconomics · 2017Review
- Mapping Between the Sydney Asthma Quality of Life Questionnaire (AQLQ-S) and Five Multi-Attribute Utility Instruments (MAUIs).PharmacoEconomics · 2017Article
- Measurement of utility in asthma: evidence indicating that generic instruments may miss clinically important changes.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2016Article
- Comparison of EQ-5D and SF-6D utilities in Pompe disease.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2015Article
- Factors associated with health-related quality of life in adults with asthma. A cross-sectional study.Multidisciplinary respiratory medicine · 2012Article
- Construction of a traditional Chinese medicine syndrome-specific outcome measure: the Kidney Deficiency Syndrome Questionnaire (KDSQ).BMC complementary and alternative medicine · 2012Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
objectiveA goal of asthma management is to improve the patient's health-related quality of life (HRQL). However, it is unclear whether HRQL instruments can discriminate across asthma control measures. The objective of this study was to evaluate the validity of generic and condition-specific preference-based instruments, in terms of their ability to distinguish asthma control.
methodsAsthma patients (n = 157) completed three generic preference-based instruments: the Health Utility Index Mark 3 (HUI-3), the EuroQol (EQ-5D), and the Short Form 6D (SF-6D) and two condition-specific questionnaires: the standardized Asthma Quality of Life Questionnaire (AQLQ(S)) and the Asthma Control Questionnaire (ACQ). The AQLQ(S) scores were converted into the condition-specific preference-based scores: the Asthma Quality of Life Utility Index (AQL-5D).
resultsThe preference-based instruments were generally able to discriminate across control measures, such as ACQ scores and magnitude of asthma medication, but were not able to discriminate for self-reported control and severity levels. These instruments also correlated with most control measures (r = 0.32-0.37). Significant relationships between AQL-5D scores and all control variables were observed.
conclusionsOverall, the AQL-5D discriminated across all levels of asthma control. The HUI-3, the EQ-5D, and the SF-6D differentiated between the highest and lowest levels of control but could not discriminate between the moderate levels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.