ArticleJournal of neurology2008
Apolipoprotein A5 gene C56G variant confers risk for the development of large-vessel associated ischemic stroke.
Article in Journal of neurology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Positive Association between APOA5 rs662799 Polymorphism and Coronary Heart Disease: A Case-Control Study and Meta-Analysis.PloS one · 2015Pooled it
- Apolipoprotein A5 gene variants and the risk of coronary heart disease: a case‑control study and meta‑analysis.Molecular medicine reports · 2013Pooled it
- Gene Influence in the Effectiveness of Plant Sterols Treatment in Children: Pilot Interventional Study.Nutrients · 2019Article
- Genomic Influence in the Prevention of Cardiovascular Diseases with a Sterol-Based Treatment.Diseases (Basel, Switzerland) · 2018Article
- INSIG2 rs7566605 single nucleotide variant and global DNA methylation index levels are associated with weight loss in a personalized weight reduction program.Molecular medicine reports · 2018Article
- Marked Differences of Haplotype Tagging SNP Distribution, Linkage, and Haplotype Profile of APOA5 Gene in Roma Population Samples.Pathology oncology research : POR · 2017Article
- Association analysis ofOncotarget · 2017Article
- Functional variants of lipid level modifier MLXIPL, GCKR, GALNT2, CILP2, ANGPTL3 and TRIB1 genes in healthy Roma and Hungarian populations.Pathology oncology research : POR · 2015Article
- Common functional variants of APOA5 and GCKR accumulate gradually in association with triglyceride increase in metabolic syndrome patients.Molecular biology reports · 2012Article
- Triglyceride level-influencing functional variants of the ANGPTL3, CILP2, and TRIB1 loci in ischemic stroke.Neuromolecular medicine · 2011Article
- Stepwise positive association between APOA5 minor allele frequencies and increasing plasma triglyceride quartiles in random patients with hypertriglyceridemia of unclarified origin.Pathology oncology research : POR · 2011Article
- Three periods of one and a half decade of ischemic stroke susceptibility gene research: lessons we have learned.Genome medicine · 2010Article
- Genetic association and interaction analysis of USF1 and APOA5 on lipid levels and atherosclerosis.Arteriosclerosis, thrombosis, and vascular biology · 2010Article
- Association of apolipoprotein A5 concentration with serum insulin and triglyceride levels and coronary artery disease in Korean men.Atherosclerosis · 2009Article
- Clinical significance of apolipoprotein A5.Current opinion in lipidology · 2008Review
- Modulation of plasma triglycerides concentration by sterol-based treatment in children carrying different genes.Annals of pediatric cardiologyArticle
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesIschemic stroke is a suddenly developing temporary or often permanent damage of the brain. Several candidate genes have been shown to have an impact in the pathogenesis of stroke. The aim of our study was to investigate the possible association between the C56G variant of the apolipoprotein A5 (APOA5) gene and ischemic stroke.
methodsPCR-RFLP assays were performed to detect the C56G alleles in 403 patients with classified stroke types and 171 controls.
resultsTriglyceride levels of subjects carrying 56G allele were elevated compared to the subjects with 56C allele in all stroke subgroups and in the controls. The serum total cholesterol levels did not differ between subjects with C or G alleles in each group. An accumulation of APOA5 56G allele was observed in the large-vessel associated stroke group compared to the healthy controls (10.9 vs. 5.6 %; p < 0.05), while its prevalence did not increase in any other stroke subgroups. Multivariate logistic regression analysis adjusted for differences in age, gender, BMI, serum total cholesterol levels, ischemic heart disease, hypertension, diabetes mellitus, smoking and drinking habits revealed that the APOA5 56G allele represents a susceptibility factor for large-vessel associated stroke (OR = 2.132 at 95 % CI; p < 0.05).
conclusionThe data presented here suggest that the 56G allele can confer risk exclusively for development of large-vessel associated stroke. Thereby, the 56G allele differs from the APOA5 T-1131C allelic variant, which has been previously identified as a risk factor for all subgroups of the stroke disease.
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