ArticleMediators of inflammation2007
Progesterone prevents traumatic brain injury-induced intestinal nuclear factor kappa B activation and proinflammatory cytokines expression in male rats.
Article in Mediators of inflammation, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 51 citations in OpenAlex.
- Assessment of the Sex Hormone Profile and Its Predictive Role in Consciousness Recovery Following Severe Traumatic Brain Injury.Life (Basel, Switzerland) · 2025Article
- The protection of sulforaphane on subarachnoid hemorrhage-induced intestinal mucosa injury in rats.Frontiers in molecular biosciences · 2025Article
- Microglia-induced neuroinflammation in hippocampal neurogenesis following traumatic brain injury.Heliyon · 2024Review
- Dysregulated brain-gut axis in the setting of traumatic brain injury: review of mechanisms and anti-inflammatory pharmacotherapies.Journal of neuroinflammation · 2024Review
- Neuroprotection or Sex Bias: A Protective Response to Traumatic Brain Injury in the Females.CNS & neurological disorders drug targets · 2024Review
- New insights into the functions of progesterone receptor (PR) isoforms and progesterone signaling.American journal of cancer research · 2021Review
- The interaction between protein kinase A and progesterone on basal and inflammation-induced myometrial oxytocin receptor expression.PloS one · 2020Article
- Rosuvastatin Alleviates Intestinal Injury by Down-Regulating the CD40 Pathway in the Intestines of Rats Following Traumatic Brain Injury.Frontiers in neurology · 2020Article
- Beneficial and Deleterious Effects of Female Sex Hormones, Oral Contraceptives, and Phytoestrogens by Immunomodulation on the Liver.International journal of molecular sciences · 2019Review
- Effects of Female Sex Steroids Administration on Pathophysiologic Mechanisms in Traumatic Brain Injury.Translational stroke research · 2018Review
- Effects of progesterone on hippocampal ultrastructure and expression of inflammatory mediators in neonatal rats with hypoxic-ischemic brain injury.Experimental and therapeutic medicine · 2014Article
- Pharmacotherapy of traumatic brain injury: state of the science and the road forward: report of the Department of Defense Neurotrauma Pharmacology Workgroup.Journal of neurotrauma · 2014Review
- Anti-inflammatory and immunomodulatory mechanisms of mesenchymal stem cell transplantation in experimental traumatic brain injury.Journal of neuroinflammation · 2013Article
- Progesterone and vitamin d hormone as a biologic treatment of traumatic brain injury in the aged.PM & R : the journal of injury, function, and rehabilitation · 2011Review
- Progesterone administration modulates cortical TLR4/NF-κB signaling pathway after subarachnoid hemorrhage in male rats.Mediators of inflammation · 2011Article
- Is progesterone a worthy candidate as a novel therapy for traumatic brain injury?Dialogues in clinical neuroscience · 2011Review
- The treatment of traumatic brain injury with velcade.Journal of neurotrauma · 2010Article
- The nongenomic effects of progesterone in repressing iNOS activation through P38MAPK pathways in gonococci-infected polymorphonuclear leukocytes and the clinical significance.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2010Article
- Combination treatment with progesterone and vitamin D hormone may be more effective than monotherapy for nervous system injury and disease.Frontiers in neuroendocrinology · 2009Review
- Progesterone decreases cortical and sub-cortical edema in young and aged ovariectomized rats with brain injury.Restorative neurology and neuroscience · 2009Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have previously shown that traumatic brain injury (TBI) can induce an upregulation of nuclear factor kappa B (NF-kappaB) and proinflammatory cytokines in the gut, which play an important role in the pathogenesis of acute gut mucosal injury mediated by inflammation. In this work, we investigated whether progesterone administration modulated intestinal NF-kappaB activity and proinflammatory cytokines expression after TBI in male rats. As a result, we found that administration of progesterone following TBI could decrease NF-kappaB binding activity, NF-kappaB p65 protein expression, and concentrations of interleukin-1beta (IL-1beta), and tumor necrosis factor-alpha (TNF-alpha) in the gut. TBI-induced damages of gut structure were ameliorated after progesterone injections. The results of the present study suggest that the therapeutic benefit of post-TBI progesterone injections might be due to its inhibitory effects on intestinal NF-kappaB activation and proinflammatory cytokines expression.
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