ArticlePPAR research2007
Is PPARbeta/delta a Retinoid Receptor?
Article in PPAR research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Review
- Vitamin A Update: Forms, Sources, Kinetics, Detection, Function, Deficiency, Therapeutic Use and Toxicity.Nutrients · 2021Review
- Resveratrol Suppresses the Growth and Enhances Retinoic Acid Sensitivity of Anaplastic Thyroid Cancer Cells.International journal of molecular sciences · 2018Article
- Review
- All-Trans-Retinoic Acid Enhances Mitochondrial Function in Models of Human Liver.Molecular pharmacology · 2016Article
- Cellular and molecular determinants of all-trans retinoic acid sensitivity in breast cancer: Luminal phenotype and RARα expression.EMBO molecular medicine · 2015Article
- Transcriptional Factors Mediating Retinoic Acid Signals in the Control of Energy Metabolism.International journal of molecular sciences · 2015Review
- Retinoid receptors in bone and their role in bone remodeling.Frontiers in endocrinology · 2015Review
- The Roles of Vitamin A in the Regulation of Carbohydrate, Lipid, and Protein Metabolism.Journal of clinical medicine · 2014Review
- Fatty acid-binding protein 5 (FABP5) regulates cognitive function both by decreasing anandamide levels and by activating the nuclear receptor peroxisome proliferator-activated receptor β/δ (PPARβ/δ) in the brain.The Journal of biological chemistry · 2014Article
- Role of stearoyl-CoA desaturase-1 in skin integrity and whole body energy balance.The Journal of biological chemistry · 2014Review
- Retinoic acid actions through mammalian nuclear receptors.Chemical reviews · 2014Review
- Vitamin A and retinoid signaling: genomic and nongenomic effects.Journal of lipid research · 2013Review
- Article
- Mechanism of inhibition of MMTV-neu and MMTV-wnt1 induced mammary oncogenesis by RARalpha agonist AM580.Oncogene · 2010Article
- Repression of cellular retinoic acid-binding protein II during adipocyte differentiation.The Journal of biological chemistry · 2010Article
- From carrot to clinic: an overview of the retinoic acid signaling pathway.Cellular and molecular life sciences : CMLS · 2010Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The broad ligand-binding characteristic of PPARbeta/delta has long hampered identification of physiologically-meaningful ligands for the receptor. The observations that the activity of PPARbeta/delta is supported by fatty acid binding protein 5 (FABP5), which directly delivers ligands from the cytosol to the receptor, suggest that bona fide PPARbeta/delta ligands both activate the receptor, and trigger the nuclear translocation of FABP5. Using these criteria, it was recently demonstrated that all-trans-retinoic acid (RA), the activator of the classical retinoic acid receptor RAR, also serves as a ligand for PPARbeta/delta. Partitioning of RA between its two receptors was found to be regulated by FABP5, which delivers it to PPARbeta/delta, and cellular RA binding protein II (CRABP-II), which targets it to RAR. Consequently, RA activates PPARbeta/delta in cells that display a high FABP5/CRABP-II expression ratio. It remains to be clarified whether compounds other than RA may also serve as endogenous activators for this highly promiscuous protein.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.