ReviewNature reviews. Drug discovery2008
Genome-wide association studies: progress and potential for drug discovery and development.
Review in Nature reviews. Drug discovery, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it, 154 citations in OpenAlex.
- Pooled it
- SAGA (Simplified Association Genome-wide Analyses): a user-friendly Pipeline to Democratize Genome-Wide Association Studies.bioRxiv : the preprint server for biology · 2025Article
- Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes.Genome biology · 2024Article
- Unveiling the Mysteries of Non-Mendelian Heredity in Plant Breeding.Plants (Basel, Switzerland) · 2023Review
- Genotype imputation for soybean nested association mapping population to improve precision of QTL detection.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Article
- 'Teratoid' Hepatoblastoma: An Intriguing Variant of Mixed Epithelial-Mesenchymal Hepatoblastoma.Children (Basel, Switzerland) · 2022Review
- Identification and functional validation of HLA-C as a potential gene involved in colorectal cancer in the Korean population.BMC genomics · 2022Article
- Thalidomide Exerts Anti-Inflammatory Effects in Cutaneous Lupus by Inhibiting the IRF4/NF-ҡB and AMPK1/mTOR Pathways.Biomedicines · 2021Article
- Glucagon-like peptide-1 receptor and sarcoglycan delta genetic variants can affect cardiovascular risk in chronic kidney disease patients under hemodialysis.Clinical kidney journal · 2020Article
- Interaction between Coffee Drinking and TRIB1 rs17321515 Single Nucleotide Polymorphism on Coronary Heart Disease in a Taiwanese Population.Nutrients · 2020Article
- GenEpi: gene-based epistasis discovery using machine learning.BMC bioinformatics · 2020Article
- Precision medicine in pediatric sepsis.Current opinion in pediatrics · 2019Review
- Genetic Architecture of Soybean Yield and Agronomic Traits.G3 (Bethesda, Md.) · 2018Article
- Drug development in the era of precision medicine.Nature reviews. Drug discovery · 2018Review
- Early Diagnosis of Sepsis: Is an Integrated Omics Approach the Way Forward?Molecular diagnosis & therapy · 2017Review
- Genetic studies of alcohol dependence in the context of the addiction cycle.Neuropharmacology · 2017Review
- Finding melanoma drugs through a probabilistic knowledge graph.PeerJ. Computer science · 2017Article
- A BAYESIAN GRAPHICAL MODEL FOR GENOME-WIDE ASSOCIATION STUDIES (GWAS).The annals of applied statistics · 2016Article
- Targeting Anti-Cancer Active Compounds: Affinity-Based Chromatographic Assays.Current pharmaceutical design · 2016Review
- New approaches to establish genetic causality.Trends in cardiovascular medicine · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Although genetic studies have been critically important for the identification of therapeutic targets in Mendelian disorders, genetic approaches aiming to identify targets for common, complex diseases have traditionally had much more limited success. However, during the past year, a novel genetic approach - genome-wide association (GWA) - has demonstrated its potential to identify common genetic variants associated with complex diseases such as diabetes, inflammatory bowel disease and cancer. Here, we highlight some of these recent successes, and discuss the potential for GWA studies to identify novel therapeutic targets and genetic biomarkers that will be useful for drug discovery, patient selection and stratification in common diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.