ArticleNeurochemical research2008
Gasping generation in developing Swiss-Webster mice in vitro and in vivo.
Article in Neurochemical research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 27 citations in OpenAlex.
- Altered PI3K/mTOR Signaling within the Forebrain Leads to Respiratory Deficits in a Mouse Model of Epilepsy.eNeuro · 2025Article
- Respiratory rhythm generation, hypoxia, and oxidative stress-Implications for development.Respiratory physiology & neurobiology · 2019Review
- Change in network connectivity during fictive-gasping generation in hypoxia: prevention by a metabolic intermediate.Frontiers in physiology · 2014Article
- Central and peripheral factors contributing to obstructive sleep apneas.Respiratory physiology & neurobiology · 2013Review
- The cellular building blocks of breathing.Comprehensive Physiology · 2012Review
- Tonic neuromodulation of the inspiratory rhythm generator.Frontiers in physiology · 2012Article
- Chapter 3--networks within networks: the neuronal control of breathing.Progress in brain research · 2011Review
- State-dependent interactions between excitatory neuromodulators in the neuronal control of breathing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Discharge of the hypoglossal nerve cannot distinguish eupnea from gasping, as defined by phrenic discharge, in the in situ mouse.Journal of applied physiology (Bethesda, Md. : 1985) · 2009Article
- Genesis of gasping is independent of levels of serotonin in the Pet-1 knockout mouse.Journal of applied physiology (Bethesda, Md. : 1985) · 2009Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During hypoxia the respiratory network produces gasping in vivo and in vitro. To understand the mechanisms involved in such response and to validate in vitro findings, correlative studies are necessary. During perinatal age gasping generation is robust and then declines during postnatal development, possibly due to changes in either the rhythm generator (the pre-Bötzinger complex, PBC) and/or its motor outputs. We tested this hypothesis by recording respiratory response to hypoxia in vivo and in vitro during postnatal development. We found that postnatal age influences: (1) The hypoxia-induced pattern change in the PBC bursts, (2) The coupling between the PBC and the XII nucleus during prolonged hypoxia and (3) The ability of mice to gasp and autoresuscitate from hypoxic conditions. We conclude that the inability of mice to gasp during late postnatal development might be determined by a progressive uncoupling between the respiratory rhythm generator and its motor outputs in hypoxia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.