ArticleParasitology research2008
An ethanolic extract of leaves of Piper betle (Paan) Linn mediates its antileishmanial activity via apoptosis.
Article in Parasitology research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Effect of selected Indonesian plants on Giardia intestinalis in an experimental in vitro model.BMC complementary medicine and therapies · 2025Article
- Betelvine (Piper betle L.): A comprehensive insight into its ethnopharmacology, phytochemistry, and pharmacological, biomedical and therapeutic attributes.Journal of cellular and molecular medicine · 2022Review
- Article
- Potential of Piper spp. as a source of new compounds for the leishmaniases treatment.Parasitology research · 2021Review
- Novel Amides Derivative with Antimicrobial Activity ofMolecules (Basel, Switzerland) · 2021Article
- Recent researches in effective antileishmanial herbal compounds: narrative review.Parasitology research · 2020Review
- Review
- Berberine chloride mediates its antileishmanial activity by inhibiting Leishmania mitochondria.Parasitology research · 2019Article
- BornylInternational journal of molecular sciences · 2018Article
- Emerging therapeutic targets for treatment of leishmaniasis.Expert opinion on therapeutic targets · 2018Review
- Apoptosis mediated leishmanicidal activity of Azadirachta indica bioactive fractions is accompanied by Th1 immunostimulatory potential and therapeutic cure in vivo.Parasites & vectors · 2015Article
- Leishmanicidal Activity of Piper nigrum Bioactive Fractions is Interceded via Apoptosis In Vitro and Substantiated by Th1 Immunostimulatory Potential In Vivo.Frontiers in microbiology · 2015Article
- Influence of phytochemicals in piper betle linn leaf extract on wound healing.Burns & trauma · 2015Article
- Resveratrol is active against Leishmania amazonensis: in vitro effect of its association with Amphotericin B.Antimicrobial agents and chemotherapy · 2014Article
- Leishmanicidal activities of Artemisia annua leaf essential oil against Visceral Leishmaniasis.Frontiers in microbiology · 2014Article
- Effect of Piper betle and Brucea javanica on the Differential Expression of Hyphal Wall Protein (HWP1) in Non-Candida albicans Candida (NCAC) Species.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Article
- Chemical and biological analyses of the essential oils and main constituents of Piper species.Molecules (Basel, Switzerland) · 2012Article
- Knockdown of LdMC1 and Hsp70 by antisense oligonucleotides causes cell-cycle defects and programmed cell death in Leishmania donovani.Molecular and cellular biochemistry · 2012Article
- Conventional therapy and promising plant-derived compounds against trypanosomatid parasites.Frontiers in microbiology · 2012Article
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
An unprecedented increase in the incidence of unresponsiveness to antimonial compounds has highlighted the urgent need to develop new antileishmanial agents. The leaves of Piper betle (locally known as Paan) have long been in use in the Indian indigenous system of medicine for its antimicrobial properties but its antileishmanial potential has not been studied. Accordingly, an ethanolic extract of leaves of Piper betle (PB) was tested for its antileishmanial activity that was evidenced in both promastigotes and amastigotes, with IC50 values of 9.8 and 5.45 microg/ml, respectively; importantly, it was accompanied by a safety index of >12-fold. This leishmanicidal activity of PB was mediated via apoptosis as evidenced by morphological changes, loss of mitochondrial membrane potential, in situ labeling of DNA fragments by terminal deoxyribonucleotidyltransferase-mediated deoxyuridine triphosphate nick end labeling, and cell-cycle arrest at the sub-G0/G1 phase. Taken together, the data indicate that PB has promising antileishmanial activity that is mediated via programmed cell death and, accordingly, merits consideration and further investigation as a therapeutic option for the treatment of leishmaniasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.