Evidence map›Paper›PMID 18273598›Full record

ReviewDer Urologe. Ausg. A2008

[Role of androgen receptors in hormone-refractory prostate cancer: molecular basics and experimental therapy approaches].

L Rinnab, A Hessenauer, S V Schütz, E Schmid, R Küfer, F Finter, R E Hautmann, K D Spindler, M V Cronauer

Abstract readEnglish AbstractReview
PubMed Publisher
In one paragraph

Review in Der Urologe. Ausg. A, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

L RinnabKlinik für Urologie und Kinderurologie, Universität Ulm, Ulm, Germany. ludwig.rinnab@uniklinik-ulm.de
A Hessenauer
S V Schütz
E Schmid
R Küfer
F Finter
R E Hautmann
K D Spindler
M V Cronauer

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of hormone-refractory prostate cancer cells is one of the major causes for the progression and high mortality rates in advanced prostate cancer (PCA). While the loss of the androgen receptor (AR) is the predominant mechanism for development of a hormone-insensitive disease in vitro, the first in vivo studies showed that the AR is still expressed or is even overexpressed in hormone-refractory PCA. In view of the increasing cases of PCA in the industrialized Western countries, a series of cell and molecular biological studies has led to the identification of various new factors and mechanisms that play a role during the development of hormone-refractory tumors. These findings should lead to the development of new therapeutic strategies.

Indexed as

Androgen AntagonistsAnimalsCell Line, TumorDNA Mutational AnalysisGene Expression RegulationHumansMaleNeoplasms, Hormone-DependentPolymorphism, GeneticPrognosisProstatic NeoplasmsRatsReceptors, AndrogenSignal TransductionAndrogen AntagonistsReceptors, Androgen

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.