ArticleNature2008
The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans.
Article in Nature, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 555 papers.
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Who cites it
555 citing papers in PubMed, 1,153 citations in OpenAlex.
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495 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
36 authors at 10 institutions in 2 countries.
Funding
Abstract
Choanoflagellates are the closest known relatives of metazoans. To discover potential molecular mechanisms underlying the evolution of metazoan multicellularity, we sequenced and analysed the genome of the unicellular choanoflagellate Monosiga brevicollis. The genome contains approximately 9,200 intron-rich genes, including a number that encode cell adhesion and signalling protein domains that are otherwise restricted to metazoans. Here we show that the physical linkages among protein domains often differ between M. brevicollis and metazoans, suggesting that abundant domain shuffling followed the separation of the choanoflagellate and metazoan lineages. The completion of the M. brevicollis genome allows us to reconstruct with increasing resolution the genomic changes that accompanied the origin of metazoans.
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Registered trials
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