Too much of a good thing: does Nek8 link polycystic kidney disease and nephronophthisis?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

4 citing papers in PubMed.

1. NEK8, a NIMA-family protein kinase at the core of the ciliary INV complex.Cell communication and signaling : CCS · 2025
   Review
2. The tumor suppressor pVHL down-regulates never-in-mitosis A-related kinase 8 via hypoxia-inducible factors to maintain cilia in human renal cancer cells.The Journal of biological chemistry · 2015
   Article
3. Genetic background of nonmutant Piebald-Virol-Glaxo rats does not influence nephronophthisis phenotypes.International journal of nephrology and renovascular disease · 2013
   Article
4. Novel targets for the treatment of autosomal dominant polycystic kidney disease.Expert opinion on investigational drugs · 2010
   Review

Corrections and comments

• Comment on
  NEK8 mutations affect ciliary and centrosomal localization and may cause nephronophthisis.2008
• Comment on
  Nek8 regulates the expression and localization of polycystin-1 and polycystin-2.2008

Authors and funding

2 authors.

Funding

Abstract

PubMed holds no abstract for this paper.

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