ArticleMolecular biology of the cell2008
RASSF7 is a member of a new family of RAS association domain-containing proteins and is required for completing mitosis.
Article in Molecular biology of the cell, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 80 citations in OpenAlex.
- A Number of the N-terminal RASSF Family: RASSF7.Anti-cancer agents in medicinal chemistry · 2024Pooled it
- Associations of prenatal exposure to NOPlacenta · 2023Article
- Rassf7a promotes spinal cord regeneration and controls spindle orientation in neural progenitor cells.EMBO reports · 2023Article
- KLF5 Is Activated by Gene Amplification in Gastric Cancer and Is Essential for Gastric Cell Proliferation.Cells · 2021Article
- TAK1 Phosphorylates RASSF9 and Inhibits Esophageal Squamous Tumor Cell Proliferation by Targeting the RAS/MEK/ERK Axis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- The non-enzymatic RAS effector RASSF7 inhibits oncogenic c-Myc function.The Journal of biological chemistry · 2018Article
- The regulation and function of microRNA-377/RASSF8 signaling axis in gastric cancer.Oncology letters · 2018Article
- Decreased expression of RASSF10 correlates with poor prognosis in patients with colorectal cancer.Medicine · 2017Article
- Primary Cilia as a Possible Link between Left-Right Asymmetry and Neurodevelopmental Diseases.Genes · 2017Review
- The value of serum RASSF10 hypermethylation as a diagnostic and prognostic tool for gastric cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Predicted protein interactions of IFITMs may shed light on mechanisms of Zika virus-induced microcephaly and host invasion.F1000Research · 2016Article
- Low RASSF6 expression in pancreatic ductal adenocarcinoma is associated with poor survival.World journal of gastroenterology · 2015Article
- RASSF10 suppresses colorectal cancer growth by activating P53 signaling and sensitizes colorectal cancer cell to docetaxel.Oncotarget · 2015Article
- RASSF7 expression and its regulatory roles on apoptosis in human intervertebral disc degeneration.International journal of clinical and experimental pathology · 2015Article
- Methylation of ras association domain protein 10 (RASSF10) promoter negative association with the survival of gastric cancer.American journal of cancer research · 2014Article
- The tumor suppressor RASSF10 is upregulated upon contact inhibition and frequently epigenetically silenced in cancer.Oncogenesis · 2012Article
- The RASSF gene family members RASSF5, RASSF6 and RASSF7 show frequent DNA methylation in neuroblastoma.Molecular cancer · 2012Article
- RASSF Signalling and DNA Damage: Monitoring the Integrity of the Genome?Molecular biology international · 2012Article
- RASSF7 negatively regulates pro-apoptotic JNK signaling by inhibiting the activity of phosphorylated-MKK7.Cell death and differentiation · 2011Article
- A novel role of RASSF9 in maintaining epidermal homeostasis.PloS one · 2011Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Mitosis is a fundamental feature of all cellular organisms. It must be tightly regulated to allow normal tissue growth and to prevent cancer formation. Here, we identify a new protein that is required for mitosis. We show that the Ras association (RA) domain-containing protein, RASSF7, is part of an evolutionarily conserved group of four proteins. These are RASSF7, RASSF8, and two new RASSF proteins P-CIP1/RASSF9 and RASSF10. We call this group the N-terminal RASSF family. We analyzed the function of Xenopus RASSF7. RASSF7 was found to be expressed in several embryonic tissues including the skin, eyes, and neural tube. Knocking down its function led to cells failing to form a mitotic spindle and arresting in mitosis. This caused nuclear breakdown, apoptosis, and a striking loss of tissue architecture in the neural tube. Consistent with a role in spindle formation, RASSF7 protein was found to localize to the centrosome. This localization occurred in a microtubule-dependent manner, demonstrating that there is a mutually dependant relationship between RASSF7 localization and spindle formation. Thus RASSF7, the first member of the N-terminal RASSF family to be functionally analyzed, is a centrosome-associated protein required to form a spindle and complete mitosis in the neural tube.
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