Evidence map›Paper›PMID 18272545›Full record

ReviewGut2008

Autophagy as an important process in gut homeostasis and Crohn's disease pathogenesis.

Ramnik J Xavier, Alan Huett, John D Rioux

Abstract readReview
In one paragraph

Review in Gut, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Experimental and therapeutic medicine · 2014
    Article
  11. Article
  12. Article
  13. IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans.Proceedings of the National Academy of Sciences of the United States of America · 2014
    Article
  14. The future for genetic studies in reproduction.Molecular human reproduction · 2014
    Review
  15. Review
  16. Article
  17. Article
  18. IRGM in autophagy and viral infections.Frontiers in immunology · 2012
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ramnik J XavierUniversité de Montréal and the Montreal Heart Institute, Research Center, 5000 Belanger Street, Montreal, Quebec H1T 1C8, Canada.
Alan Huett
John D Rioux

Funding

Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG · 1991 to 2026
$35.3M
The Slamf3, Slamf5, and Slamf6 receptor-induced pathways to murine lupusP01AI065687 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI TERHORST, CORNELIS P · 2006 to 2016
$14.7M
Systemic Lupus Erythematosus and Ulcerative Colitis StudyU19AI067152 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KLARESKOG, LARS · 2005 to 2009
$10.1M
Universite de Montreal IBD Genetics Research CenterU01DK062432 · NIDDK · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI John D. Rioux · 2002 to 2026
$9.6M
Identification of the IBD genes on chromosomes 3p and 6pR01DK064869 · NIDDK · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI RIOUX, JOHN D. · 2003 to 2016
$7.8M
Genomic Approaches to Host-Pathogen InteractionsR01AI062773 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI XAVIER, RAMNIK J · 2006 to 2009
$1.4M
NIAID NIH HHS AI062773NIAID NIH HHS AI065687NIAID NIH HHS AI067152NIAID NIH HHS P01 AI065687NIAID NIH HHS R01 AI062773NIAID NIH HHS U19 AI067152NIDDK NIH HHS DK062432NIDDK NIH HHS DK064869NIDDK NIH HHS DK43351NIDDK NIH HHS P30 DK043351NIDDK NIH HHS R01 DK064869NIDDK NIH HHS U01 DK062432
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AutophagyAutophagy-Related ProteinsCarrier ProteinsCrohn DiseaseGastrointestinal TractGenetic Predisposition to DiseaseGTP-Binding ProteinsHomeostasisHumansATG16L1 protein, humanAutophagy-Related ProteinsCarrier ProteinsGTP-Binding ProteinsIRGM protein, human

Identifiers

PMID18272545
PMCPMC2735854

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.