ArticleThe Journal of biological chemistry2008
A distinctive physiological role for IkappaBbeta in the propagation of mitochondrial respiratory stress signaling.
Article in The Journal of biological chemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
- Absence of IκBβ/NFκB signaling does not attenuate acetaminophen-induced hepatic injury.Anatomical record (Hoboken, N.J. : 2007) · 2025Article
- Unraveling the role and mechanism of mitochondria in postoperative cognitive dysfunction: a narrative review.Journal of neuroinflammation · 2024Review
- Mitochondrial Metabolism in Pancreatic Ductal Adenocarcinoma: From Mechanism-Based Perspectives to Therapy.Cancers · 2023Review
- CK2 and the Hallmarks of Cancer.Biomedicines · 2022Review
- Nuclear-Mitochondrial Interactions.Biomolecules · 2022Review
- Chronic aryl hydrocarbon receptor activity phenocopies smoking-induced skeletal muscle impairment.Journal of cachexia, sarcopenia and muscle · 2022Article
- Lower threshold to NFκB activity sensitizes murine β-cells to streptozotocin.The Journal of endocrinology · 2021Article
- Dysregulation of RyR Calcium Channel Causes the Onset of Mitochondrial Retrograde Signaling.iScience · 2020Article
- CpG-ODN-mediated TLR9 innate immune signalling and calcium dyshomeostasis converge on the NFκB inhibitory protein IκBβ to drive IL1α and IL1β expression.Immunology · 2020Article
- Dietary Melatonin Supplementation Could Be a Promising Preventing/Therapeutic Approach for a Variety of Liver Diseases.Nutrients · 2018Review
- Simulation of Cellular Energy Restriction in Quiescence (ERiQ)-A Theoretical Model for Aging.Biology · 2017Article
- Mitochondrial determinants of cancer health disparities.Seminars in cancer biology · 2017Review
- Mitochondrial dysfunction and mitochondrial dynamics-The cancer connection.Biochimica et biophysica acta. Bioenergetics · 2017Review
- Calcineurin/nuclear factor-κB signaling mediates isoflurane-induced hippocampal neuroinflammation and subsequent cognitive impairment in aged rats.Molecular medicine reports · 2017Article
- Role of mitochondrial dysfunction in cancer progression.Experimental biology and medicine (Maywood, N.J.) · 2016Review
- Divergent branches of mitochondrial signaling regulate specific genes and the viability of specialized cell types of differentiated yeast colonies.Oncotarget · 2016Article
- Disruption of cytochrome c oxidase function induces the Warburg effect and metabolic reprogramming.Oncogene · 2016Article
- Article
- Distinct Cell Stress Responses Induced by ATP Restriction in Quiescent Human Fibroblasts.Frontiers in genetics · 2016Article
- HnRNPA2 is a novel histone acetyltransferase that mediates mitochondrial stress-induced nuclear gene expression.Cell discovery · 2016Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The NFkappaBs regulate an array of physiological and pathological processes, including propagation of mitochondrial respiratory stress signaling in mammalian cells. We showed previously that mitochondrial stress activates NFkappaB using a novel calcineurin-requiring pathway that is different from canonical or non-canonical pathways. This study shows that IkappaBbeta is essential for the propagation of mitochondrial stress signaling. Knock down of IkappaBbeta, but not IkappaBalpha, mRNA reduced the mitochondrial stress-mediated activation and nuclear translocation of cRel:p50, inhibiting expression of nuclear target genes RyR1 and cathepsin L. IkappaBbeta mRNA knock down also reduced resistance to staurosporine-induced apoptosis and decreased in vitro invasiveness. Induced receptor switching to insulin-like growth factor-1 receptor and increased glucose uptake are hallmarks of mitochondrial stress. IkappaBbeta mRNA knock down selectively abrogated the receptor switch and altered tubulin cytoskeletal organization. These results show that mitochondrial stress signaling uses an IkappaBbeta-initiated NFkappaB pathway that is distinct from the other known NFkappaB pathways. Furthermore, our results demonstrate the distinctive physiological roles of the two inhibitory proteins IkappaBbeta and IkappaBalpha.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.