ArticleProceedings of the National Academy of Sciences of the United States of America2008
Wound angiogenesis as a function of tissue oxygen tension: a mathematical model.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 184 citations in OpenAlex.
- Boron in wound healing: a comprehensive investigation of its diverse mechanisms.Frontiers in bioengineering and biotechnology · 2024Review
- Self-organized and directed branching results in optimal coverage in developing dermal lymphatic networks.Nature communications · 2023Article
- Modelling the Effect of Matrix Metalloproteinases in Dermal Wound Healing.Bulletin of mathematical biology · 2023Article
- Link between cesarean section scar defect and secondary infertility: Case reports and review.JBRA assisted reproduction · 2023Review
- Angiogenic Microvascular Wall Shear Stress Patterns Revealed Through Three-dimensional Red Blood Cell Resolved Modeling.Function (Oxford, England) · 2023Article
- On the role of mechanical signals on sprouting angiogenesis through computer modeling approaches.Biomechanics and modeling in mechanobiology · 2022Review
- On modeling the multiscale mechanobiology of soft tissues: Challenges and progress.Biophysics reviews · 2022Review
- What good is maths in studies of wound healing?iScience · 2022Review
- Simulating the behaviour of glioblastoma multiforme based on patient MRI during treatments.Journal of mathematical biology · 2022Article
- Advances in non-invasive biosensing measures to monitor wound healing progression.Frontiers in bioengineering and biotechnology · 2022Review
- Mathematical Modeling Can Advance Wound Healing Research.Advances in wound care · 2021Review
- Use of Magnetic Resonance Imaging (MRI) in the Management of Diagnostic Uncertainty in Low-Resource Settings: A Case Report of Cesarean Ectopic Pregnancy in a Tertiary Hospital in Ghana.The American journal of case reports · 2020Article
- Hysteroscopic treatment of cesarean scar defect.Archives of gynecology and obstetrics · 2020Article
- Identifying possible risk factors for cesarean scar pregnancy based on a retrospective study of 291 cases.The journal of obstetrics and gynaecology research · 2020Article
- Chemoreactive Nanotherapeutics by Metal Peroxide Based Nanomedicine.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Review
- Three-dimensional numerical simulation of soft-tissue wound healing using constrained-mixture anisotropic hyperelasticity and gradient-enhanced damage mechanics.Journal of the Royal Society, Interface · 2020Article
- Influences of sodium and glycosaminoglycans on skin oedema and the potential for ulceration: a finite-element approach.Royal Society open science · 2019Article
- Identifying important parameters in the inflammatory process with a mathematical model of immune cell influx and macrophage polarization.PLoS computational biology · 2019Article
- Experimental and computational analyses reveal dynamics of tumor vessel cooption and optimal treatment strategies.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Predictive Approach Identifies Molecular Targets and Interventions to Restore Angiogenesis in Wounds With Delayed Healing.Frontiers in physiology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 1 country.
Funding
Abstract
Wound healing represents a well orchestrated reparative response that is induced by injuries. Angiogenesis plays a central role in wound healing. In this work, we sought to develop the first mathematical model directed at addressing the role of tissue oxygen tension on cutaneous wound healing. Key components of the developed model include capillary tips, capillary sprouts, fibroblasts, inflammatory cells, chemoattractants, oxygen, and the extracellular matrix. The model consists of a system of nonlinear partial differential equations describing the interactions in space and time of these variables. The simulated results agree with the reported literature on the biology of wound healing. The proposed model represents a useful tool to analyze strategies for improved healing and generate a hypothesis for experimental testing.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.