ArticleJournal of hepatology2008
Augmenter of liver regeneration: an important intracellular survival factor for hepatocytes.
Article in Journal of hepatology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
36 citing papers in PubMed, 78 citations in OpenAlex.
- Augmenter of Liver Regeneration Monoclonal Antibody Promotes Apoptosis of Hepatocellular Carcinoma Cells.Journal of clinical and translational hepatology · 2023Article
- Augmenter of liver regeneration ameliorates ischemia-reperfusion injury in steatotic liver via inhibition of the TLR4/NF-κB pathway.Experimental and therapeutic medicine · 2021Article
- Hepatic Deficiency of Augmenter of Liver Regeneration Predisposes to Nonalcoholic Steatohepatitis and Fibrosis.Hepatology (Baltimore, Md.) · 2020Observational
- Review
- Augmenter of liver regeneration protects the kidney from ischaemia-reperfusion injury in ferroptosis.Journal of cellular and molecular medicine · 2019Article
- Augmenter of liver regeneration protein deficiency promotes hepatic steatosis by inducing oxidative stress and microRNA-540 expression.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- TGF-β induces liver fibrosis via miRNA-181a-mediated down regulation of augmenter of liver regeneration in hepatic stellate cells.PloS one · 2019Article
- Lack of hepatic stimulator substance expression promotes hepatocellular carcinoma metastasis partly through ERK-activated epithelial-mesenchymal transition.Laboratory investigation; a journal of technical methods and pathology · 2018Article
- Augmenter of liver regeneration (ALR) regulates acute pancreatitis via inhibiting HMGB1/TLR4/NF-κB signaling pathway.American journal of translational research · 2018Article
- Nimbolide attenuate the lipid accumulation, oxidative stress and antioxidant in primary hepatocytes.Molecular biology reports · 2017Article
- Augmenter of liver regeneration: A fundamental life protein.Hepatology (Baltimore, Md.) · 2017Review
- "Thinking" vs. "Talking": Differential Autocrine Inflammatory Networks in Isolated Primary Hepatic Stellate Cells and Hepatocytes under Hypoxic Stress.Frontiers in physiology · 2017Article
- Attenuated lipotoxicity and apoptosis is linked to exogenous and endogenous augmenter of liver regeneration by different pathways.PloS one · 2017Article
- The Level of ALR is Regulated by the Quantity of Mitochondrial DNA.Pathology oncology research : POR · 2016Article
- Hepatic Deficiency of Augmenter of Liver Regeneration Exacerbates Alcohol-Induced Liver Injury and Promotes Fibrosis in Mice.PloS one · 2016Article
- Knockdown of augmenter of liver regeneration in HK-2 cells inhibits inflammation response via the mitogen-activated protein kinase signaling pathway.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2015Article
- Autophagy in anti-apoptotic effect of augmenter of liver regeneration in HepG2 cells.World journal of gastroenterology · 2015Article
- Liver-specific deletion of augmenter of liver regeneration accelerates development of steatohepatitis and hepatocellular carcinoma in mice.Gastroenterology · 2015Article
- Augmenter of liver regeneration ameliorates renal fibrosis in rats with obstructive nephropathy.Bioscience reports · 2014Article
- Involvement of hepatic stimulator substance in the regulation of hepatoblast maturation into hepatocytes in vitro.Stem cells and development · 2014Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
BACKGROUND/
aimsAugmenter of liver regeneration (ALR), a protein synthesized and stored in hepatocytes, is associated with mitochondria, and possesses sulfhydryl oxidase and cytochrome c reductase activities. We sought to determine the effects of ALR depletion in hepatocytes by antisense oligonucleotide transfection.
methodsRat hepatocytes in primary culture were transfected with antisense oligonucleotide for ALR mRNA (ALR-AS) or scrambled oligonucleotide. Various analyses were performed at times up to 24h after transfection.
resultsTreatment with ALR-AS caused a decrease in ALR mRNA, cellular depletion of ALR protein primarily from mitochondria, and decreased viability. Flow cytometric analysis of ALR-AS-transfected hepatocytes stained with annexin-Vcy3 and 7-aminoactinomycin D revealed apoptosis as the predominant cause of death up to 6h; incubation beyond this time resulted in necrosis in addition to apoptosis. ALR-AS-transfection caused release of mitochondrial cytochrome c, activation of caspase-3, profound reduction in the ATP content, and cellular release of LDH. Inhibition of caspase-3 inhibited the early phase of ALR-AS-induced death but not the late phase that included ALR and LDH release.
conclusionsThese results suggest that ALR is critically important for the survival of hepatocytes by its association with mitochondria and regulation of ATP synthesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.