ArticleDevelopmental biology2008
Target-dependent inhibition of sympathetic neuron growth via modulation of a BMP signaling pathway.
Article in Developmental biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 23 citations in OpenAlex.
- Decoding Cardiac Development and Maturation at Single-Cell and Spatial Transcriptomic Resolution.Circulation research · 2026Review
- Molecular and cellular neurocardiology in heart disease.The Journal of physiology · 2025Review
- Article
- Heightened sympathetic neuron activity and altered cardiomyocyte properties in spontaneously hypertensive rats during the postnatal period.Frontiers in synaptic neuroscience · 2022Article
- Beneficial Effects of Vitamin K Status on Glycemic Regulation and Diabetes Mellitus: A Mini-Review.Nutrients · 2020Review
- Inactive matrix gla protein plasma levels are associated with peripheral neuropathy in Type 2 diabetes.PloS one · 2020Article
- Integrated Proteomics and Lipidomics Investigation of the Mechanism Underlying the Neuroprotective Effect ofMolecules (Basel, Switzerland) · 2018Article
- Diabetes negatively affects cortical and striatal GABAergic neurons: an effect that is partially counteracted by exendin-4.Bioscience reports · 2016Article
- Agonists and Antagonists of TGF-β Family Ligands.Cold Spring Harbor perspectives in biology · 2016Review
- Molecular and cellular neurocardiology: development, and cellular and molecular adaptations to heart disease.The Journal of physiology · 2016Review
- Innervating sympathetic neurons regulate heart size and the timing of cardiomyocyte cell cycle withdrawal.The Journal of physiology · 2015Article
- Bone morphogenetic protein-2/-4 upregulation promoted by endothelial cells in coculture enhances mouse embryoid body differentiation.Stem cells and development · 2013Article
- The BMP coreceptor RGMb promotes while the endogenous BMP antagonist noggin reduces neurite outgrowth and peripheral nerve regeneration by modulating BMP signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Development of axon-target specificity of ponto-cerebellar afferents.PLoS biology · 2011Article
- Transcriptional responses of cultured rat sympathetic neurons during BMP-7-induced dendritic growth.PloS one · 2011Article
- Agrin binds BMP2, BMP4 and TGFbeta1.PloS one · 2010Article
- Roles of glial cells in synapse development.Cellular and molecular life sciences : CMLS · 2009Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Target-derived factors modulate many aspects of peripheral neuron development including neuronal growth, survival, and maturation. Less is known about how initial target contact regulates changes in gene expression associated with these developmental processes. One early consequence of contact between growing sympathetic neurons and their cardiac myocyte targets is the inhibition of neuronal outgrowth. Analysis of neuronal gene expression following this contact revealed coordinate regulation of a bone morphogenetic protein (BMP)-dependent growth pathway in which basic helix-loop-helix transcription factors and downstream neurofilament expression contribute to the growth dynamics of developing sympathetic neurons. BMP2 had dose-dependent growth-promoting effects on sympathetic neurons cultured in the absence, but not the presence, of myocyte targets, suggesting that target contact alters neuronal responses to BMP signaling. Target contact also induced the expression of matrix Gla protein (MGP), a regulator of BMP function in the vascular system. Increased MGP expression inhibited BMP-dependent neuronal growth and MGP expression increased in sympathetic neurons during the period of target contact in vivo. These experiments establish MGP as a novel regulator of BMP function in the nervous system, and define developmental transitions in BMP responses during sympathetic development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.