ArticleBreast cancer research : BCR2008
ESR1 and EGF genetic variation in relation to breast cancer risk and survival.
Article in Breast cancer research : BCR, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 4 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 4 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Genome-wide association study of germline variants and breast cancer-specific mortality.British journal of cancer · 2019Pooled it
- Identification of novel genetic markers of breast cancer survival.Journal of the National Cancer Institute · 2015Pooled it
- Common germline polymorphisms associated with breast cancer-specific survival.Breast cancer research : BCR · 2015Pooled it
- Association between EGF promoter polymorphisms and cancer risk: a meta-analysis.Medical oncology (Northwood, London, England) · 2010Pooled it
- Prevalence of ESR1 Mutation in Chinese ER-Positive Breast Cancer.OncoTargets and therapy · 2020Article
- ENPP1 and ESR1 genotypes associated with subclassifications of craniofacial asymmetry and severity of temporomandibular disorders.American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics · 2017Article
- Comprehensive genetic assessment of the ESR1 locus identifies a risk region for endometrial cancer.Endocrine-related cancer · 2015Article
- Association of estrogen receptor-α A908G (K303R) mutation with breast cancer risk.International journal of clinical and experimental medicine · 2013Article
- Estrogen receptor alpha gene polymorphisms and risk of HBV-related acute liver failure in the Chinese population.BMC medical genetics · 2012Article
- Estrogen receptor genes variations and breast cancer risk in Iran.International journal of clinical and experimental medicine · 2012Article
- Genetic variation of ESR1 and its co-activator PPARGC1B is synergistic in augmenting the risk of estrogen receptor-positive breast cancer.Breast cancer research : BCR · 2011Article
- Estrogen receptor alpha polymorphisms and the risk of malignancies.Pathology oncology research : POR · 2010Article
- Common genetic variability in ESR1 and EGF in relation to endometrial cancer risk and survival.British journal of cancer · 2009Article
- Association of ESR1 gene tagging SNPs with breast cancer risk.Human molecular genetics · 2009Article
- Sex steroid metabolism polymorphisms and mammographic density in pre- and early perimenopausal women.Breast cancer research : BCR · 2009Article
- Estrogen receptor alpha gene polymorphism and endometrial cancer risk--a case-control study.BMC cancer · 2008Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 3 countries.
Funding
Abstract
introductionOestrogen exposure is a central factor in the development of breast cancer. Oestrogen receptor alpha (ESR1) is the main mediator of oestrogen effect in breast epithelia and has also been shown to be activated by epidermal growth factor (EGF). We sought to determine if common genetic variation in the ESR1 and EGF genes affects breast cancer risk, tumour characteristics or breast cancer survival.
methodsWe genotyped 157 single nucleotide polymorphisms (SNPs) in ESR1 and 54 SNPs in EGF in 92 Swedish controls and selected haplotype tagging SNPs (tagSNPs) that could predict both single SNP and haplotype variation in the genes with an R2 of at least 0.8. The tagSNPs were genotyped in 1,590 breast cancer cases and 1,518 controls, and their association with breast cancer risk, tumour characteristics and survival were assessed using unconditional logistic regression models, Cox proportional hazard models and haplotype analysis.
resultsThe single tagSNP analysis did not reveal association evidence for breast cancer risk, tumour characteristics, or survival. A multi-locus analysis of five adjacent tagSNPs suggested a region in ESR1 (between rs3003925 and rs2144025) for association with breast cancer risk (p = 0.001), but the result did not withstand adjustment for multiple comparisons (p = 0.086). A similar region was also implicated by haplotype analyses, but its significance needs to be verified by follow-up analysis.
conclusionOur results do not support a strong association between common variants in the ESR1 and EGF genes and breast cancer risk, tumour characteristics or survival.
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