ArticleNeurochemical research2008
Presynaptic modulation by somatostatin in the neostriatum.
Article in Neurochemical research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Neuropeptidergic systems in psychiatric disorders.Frontiers in endocrinology · 2025Review
- Somatostatin peptide signaling dampens cortical circuits and promotes exploratory behavior.Cell reports · 2023Article
- Somatostatin enhances visual processing and perception by suppressing excitatory inputs to parvalbumin-positive interneurons in V1.Science advances · 2020Article
- Article
- A Motivational and Neuropeptidergic Hub: Anatomical and Functional Diversity within the Nucleus Accumbens Shell.Neuron · 2019Review
- Somatostatin Gene and Protein Expression in the Non-human Primate Central Extended Amygdala.Neuroscience · 2019Article
- Transcriptional and physiological adaptations in nucleus accumbens somatostatin interneurons that regulate behavioral responses to cocaine.Nature communications · 2018Article
- Decreased Numbers of Somatostatin-Expressing Neurons in the Amygdala of Subjects With Bipolar Disorder or Schizophrenia: Relationship to Circadian Rhythms.Biological psychiatry · 2017Article
- Somatostatin and Somatostatin-Containing Neurons in Shaping Neuronal Activity and Plasticity.Frontiers in neural circuits · 2016Review
- Complex autonomous firing patterns of striatal low-threshold spike interneurons.Journal of neurophysiology · 2012Article
- Serotonin inhibits low-threshold spike interneurons in the striatum.The Journal of physiology · 2012Article
- Somatostatinergic systems: an update on brain functions in normal and pathological aging.Frontiers in endocrinology · 2012Article
- A novel functionally distinct subtype of striatal neuropeptide Y interneuron.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Genetic disruption of Met signaling impairs GABAergic striatal development and cognition.Neuroscience · 2011Article
- Distinct roles of GABAergic interneurons in the regulation of striatal output pathways.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Heterogeneity and diversity of striatal GABAergic interneurons.Frontiers in neuroanatomy · 2010Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Medium spiny projection neurons (MSNs) are the main neuronal population in the neostriatum. MSNs are inhibitory and GABAergic. MSNs connect with other MSNs via local axon collaterals that produce lateral inhibition, which is thought to select cell assemblies for motor action. MSNs also receive inhibitory inputs from GABAergic local interneurons. This work shows, through the use of the paired pulse protocol, that somatostatin (SST) acts presynaptically to regulate GABA release from the terminals interconnecting MSNs. This SST action is reversible and not mediated through the release of dopamine. It is blocked by the SST receptor (SSTR) antagonist ciclosomatostatin (cicloSST). In contrast, SST does not regulate inhibition coming from interneurons. Because, SST is released by a class of local interneuron, it is concluded that this neuron helps to regulate the selection of motor acts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.