ArticleNaunyn-Schmiedeberg's archives of pharmacology2008
Antinociceptive and anti-inflammatory effects of a mucin-binding agglutinin isolated from the red marine alga Hypnea cervicornis.
Article in Naunyn-Schmiedeberg's archives of pharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 70 citations in OpenAlex.
- Macrophage modulation accounts for the anti-inflammatory effect of Hypnea cervicornis agglutinin in rat arthritis induced by zymosan.Glycoconjugate journal · 2026Article
- Antioxidant, Anti-Inflammatory and Anticancer Peptides from Extreme Marine Environments.Antioxidants (Basel, Switzerland) · 2026Review
- Plant lectins as potent Anti-coronaviruses, Anti-inflammatory, antinociceptive and antiulcer agents.Saudi journal of biological sciences · 2022Review
- Anticancer Effects of New Ceramides Isolated from the Red Sea Red AlgaeMarine drugs · 2022Article
- Purification, Partial Characterization, and Evaluation of the Antiulcer Activity ofProtein and peptide letters · 2022Article
- Article
- Lectins from red algae and their biomedical potential.Journal of applied phycology · 2018Review
- A novel N-acetyl-glucosamine lectin of Lonchocarpus araripensis attenuates acute cellular inflammation in mice.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2016Article
- Dual effects of a lectin from the green seaweed Caulerpa cupressoides var. lycopodium on inflammatory mediators in classical models of inflammation.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2015Article
- Marine lectins and their medicinal applications.Applied microbiology and biotechnology · 2015Review
- Novel κ-opioid receptor agonist MB-1C-OH produces potent analgesia with less depression and sedation.Acta pharmacologica Sinica · 2015Article
- Algal lectins as promising biomolecules for biomedical research.Critical reviews in microbiology · 2015Review
- Sulfated polysaccharides isolated from the green seaweed Caulerpa racemosa plays antinociceptive and anti-inflammatory activities in a way dependent on HO-1 pathway activation.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2014Article
- Marine algal natural products with anti-oxidative, anti-inflammatory, and anti-cancer properties.Cancer cell international · 2013Article
- Antinociceptive and anti-inflammatory activities of crude methanolic extract of red alga Bryothamnion triquetrum.Marine drugs · 2012Article
- Antinociceptive and anti-inflammatory effects of a lectin-like substance from Clitoria fairchildiana R. Howard seeds.Molecules (Basel, Switzerland) · 2012Article
- Sterols from the red algae, Gracilaria salicornia and Hypnea flagelliformis, from Persian Gulf.Pharmacognosy magazine · 2011Article
- Marine pharmacology in 2007-8: Marine compounds with antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiprotozoal, antituberculosis, and antiviral activities; affecting the immune and nervous system, and other miscellaneous mechanisms of action.Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2011Review
- An anti-inflammatory lectin from Luetzelburgia auriculata seeds inhibits adhesion and rolling of leukocytes and modulates histamine and PGE2 action in acute inflammation models.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2010Article
- Antinociceptive activity and toxicology of the lectin from Canavalia boliviana seeds in mice.Naunyn-Schmiedeberg's archives of pharmacology · 2009Article
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The agglutinin from the red marine alga Hypnea cervicornis (HCA) was tested in models of nociception and inflammation. The role of carbohydrate-binding sites and the systemic toxicity were assessed. HCA (10(-1), 1, and 10 mg/kg) administered i.v. to mice inhibited writhes induced by acetic acid and, at 10 mg/kg, inhibited the second phase of the formalin test, but did not alter the response latency in the hot-plate test. HCA (1 mg/kg) administered i.v. to rats reduced carrageenan-induced paw edema at 1, 2, and 3 h after challenge, but not edema induced by dextran. The neutrophil migration induced by both N-formyl-methionyl-leucyl-phenylalanine (fMLP) and carrageenan was inhibited by HCA at 10(-1), 1, and 10 mg/kg. The combination of HCA (1 mg/kg) and its ligand mucin reversed the lectin inhibitory effect on carrageenan-induced neutrophil migration and acetic acid-induced writhes. The i.v. treatment of rats with HCA (1 mg/kg) for 7 days did not affect body mass; liver, kidney or heart wet weight; blood leukocyte counts; urea, creatinine or serum transaminase activity; or macroscopy of the organs examined. In short, H. cervicornis agglutinin showed important antinociceptive and anti-inflammatory activity via interaction with the lectin carbohydrate-binding site.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.