ArticlePloS one2008
Delayed rectifier and A-type potassium channels associated with Kv 2.1 and Kv 4.3 expression in embryonic rat neural progenitor cells.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 34 citations in OpenAlex.
- The Designer Drug αPHP Affected Cell Proliferation and Triggered Deathly Mechanisms in Murine Neural Stem/Progenitor Cells.Biology · 2023Article
- Sequential Application of Discrete Topographical Patterns Enhances Derivation of Functional Mesencephalic Dopaminergic Neurons from Human Induced Pluripotent Stem Cells.Scientific reports · 2018Article
- It's Electric: When Technology Gives a Boost to Stem Cell Science.Current stem cell reports · 2018Article
- Electromagnetic Fields for the Regulation of Neural Stem Cells.Stem cells international · 2017Review
- Two outward potassium current types are expressed during the neural differentiation of neural stem cells.Neural regeneration research · 2013Article
- Kv3.1 channels stimulate adult neural precursor cell proliferation and neuronal differentiation.The Journal of physiology · 2013Article
- Article
- Spatial domains of progenitor-like cells and functional complexity of a stem cell niche in the neonatal rat spinal cord.Stem cells (Dayton, Ohio) · 2012Article
- Bioelectric state and cell cycle control of Mammalian neural stem cells.Stem cells international · 2012Article
- Article
- Pre- and postnatal differences in membrane, action potential, and ion channel properties of rostral nucleus of the solitary tract neurons.Journal of neurophysiology · 2011Article
- Functional ion channels in stem cells.World journal of stem cells · 2011Article
- Article
- Neural stem/progenitor cells derived from the embryonic dorsal telencephalon of D6/GFP mice differentiate primarily into neurons after transplantation into a cortical lesion.Cellular and molecular neurobiology · 2010Article
- Electrical excitability of early neurons in the human cerebral cortex during the second trimester of gestation.Cerebral cortex (New York, N.Y. : 1991) · 2009Article
- Characterization of voltage-gated potassium channels in human neural progenitor cells.PloS one · 2009Article
- Gene profiles and electrophysiology of doublecortin-expressing cells in the subventricular zone after ischemic stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2009Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBecause of the importance of voltage-activated K(+) channels during embryonic development and in cell proliferation, we present here the first description of these channels in E15 rat embryonic neural progenitor cells derived from the subventricular zone (SVZ). Activation, inactivation, and single-channel conductance properties of recorded progenitor cells were compared with those obtained by others when these Kv gene products were expressed in oocytes. METHODOLOGY/PRINCIPAL
findingsNeural progenitor cells derived from the subventricular zone of E15 embryonic rats were cultured under conditions that did not promote differentiation. Immunocytochemical and Western blot assays for nestin expression indicated that almost all of the cells available for recording expressed this intermediate filament protein, which is generally accepted as a marker for uncommitted embryonic neural progenitor cells. However, a very small numbers of the cells expressed GFAP, a marker for astrocytes, O4, a marker for immature oligodendrocytes, and betaIII-tubulin, a marker for neurons. Using immunocytochemistry and Western blots, we detected consistently the expression of Kv2.1, and 4.3. In whole-cell mode, we recorded two outward currents, a delayed rectifier and an A-type current. CONCLUSIONS/SIGNIFICANCE: We conclude that Kv2.1, and 4.3 are expressed in E15 SVZ neural progenitor cells, and we propose that they may be associated with the delayed-rectifier and the A-type currents, respectively, that we recorded. These results demonstrate the early expression of delayed rectifier and A-type K(+) currents and channels in embryonic neural progenitor cells prior to the differentiation of these cells.
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