ArticlePloS one2008
Evidence-based annotation of the malaria parasite's genome using comparative expression profiling.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed.
- Long lived liver-resident memory T cells of biased specificities for abundant sporozoite antigens drive malaria protection by radiation-attenuated sporozoite vaccination.PLoS pathogens · 2025Article
- Decrypting the complexity of the human malaria parasite biology through systems biology approaches.Frontiers in systems biology · 2022Article
- Transcriptome analysis of Plasmodium berghei during exo-erythrocytic development.Malaria journal · 2019Article
- The Development of Whole Sporozoite Vaccines forFrontiers in immunology · 2018Review
- Profiling the Targets of Protective CD8Molecular therapy. Methods & clinical development · 2017Article
- Genomics of apicomplexan parasites.Critical reviews in biochemistry and molecular biology · 2017Review
- A Knockout Screen of ApiAP2 Genes Reveals Networks of Interacting Transcriptional Regulators Controlling the Plasmodium Life Cycle.Cell host & microbe · 2017Article
- A Novel and Conserved Plasmodium Sporozoite Membrane Protein SPELD is Required for Maturation of Exo-erythrocytic Forms.Scientific reports · 2017Article
- Plasmodium falciparum ookinete expression of plasmepsin VII and plasmepsin X.Malaria journal · 2016Article
- Functional profiles of orphan membrane transporters in the life cycle of the malaria parasite.Nature communications · 2016Article
- The Plasmodium berghei translocon of exported proteins reveals spatiotemporal dynamics of tubular extensions.Scientific reports · 2015Article
- Protection of Malian children from clinical malaria is associated with recognition of multiple antigens.Malaria journal · 2015Article
- A comprehensive evaluation of rodent malaria parasite genomes and gene expression.BMC biology · 2014Article
- Role of calcium signaling in the transcriptional regulation of the apicoplast genome of Plasmodium falciparum.BioMed research international · 2014Article
- Plasmodium dipeptidyl aminopeptidases as malaria transmission-blocking drug targets.Antimicrobial agents and chemotherapy · 2013Article
- Immunization with apical membrane antigen 1 confers sterile infection-blocking immunity against Plasmodium sporozoite challenge in a rodent model.Infection and immunity · 2013Article
- A T-cell response to a liver-stage Plasmodium antigen is not boosted by repeated sporozoite immunizations.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Translational control in Plasmodium and toxoplasma parasites.Eukaryotic cell · 2013Review
- Why are male malaria parasites in such a rush?: Sex-specific evolution and host-parasite interactions.Evolution, medicine, and public health · 2013Article
- Comparative Genomics and Systems Biology of Malaria ParasitesCurrent bioinformatics · 2012Article
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16 authors.
Funding
Abstract
A fundamental problem in systems biology and whole genome sequence analysis is how to infer functions for the many uncharacterized proteins that are identified, whether they are conserved across organisms of different phyla or are phylum-specific. This problem is especially acute in pathogens, such as malaria parasites, where genetic and biochemical investigations are likely to be more difficult. Here we perform comparative expression analysis on Plasmodium parasite life cycle data derived from P. falciparum blood, sporozoite, zygote and ookinete stages, and P. yoelii mosquito oocyst and salivary gland sporozoites, blood and liver stages and show that type II fatty acid biosynthesis genes are upregulated in liver and insect stages relative to asexual blood stages. We also show that some universally uncharacterized genes with orthologs in Plasmodium species, Saccharomyces cerevisiae and humans show coordinated transcription patterns in large collections of human and yeast expression data and that the function of the uncharacterized genes can sometimes be predicted based on the expression patterns across these diverse organisms. We also use a comprehensive and unbiased literature mining method to predict which uncharacterized parasite-specific genes are likely to have roles in processes such as gliding motility, host-cell interactions, sporozoite stage, or rhoptry function. These analyses, together with protein-protein interaction data, provide probabilistic models that predict the function of 926 uncharacterized malaria genes and also suggest that malaria parasites may provide a simple model system for the study of some human processes. These data also provide a foundation for further studies of transcriptional regulation in malaria parasites.
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