ArticlePloS one2008
Higher infection of dengue virus serotype 2 in human monocytes of patients with G6PD deficiency.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- A genus-wide interaction atlas across NS4B orthologues identifies a conserved role for UFMylation in orthoflavivirus replication.Nature communications · 2026Article
- Spectrum of glucose-6-phosphate dehydrogenase (G6PD) mutations and trends in hemoglobin levels among adult dengue patients in Thailand.PloS one · 2025Article
- Severity of oxidative stress as a hallmark in COVID-19 patients.European journal of medical research · 2023Article
- Angiotensin II and dengue.Archives of virology · 2023Review
- Hemoglobinopathies, merozoite surface protein-2 gene polymorphisms, and acquisition of Epstein Barr virus among infants in Western Kenya.BMC cancer · 2023Article
- Understanding Immune Responses to Viruses-Do Underlying Th1/Th2 Cell Biases Predict Outcome?Viruses · 2022Review
- Hematologic Outcomes of COVID-19 Patients with and without G6PD Deficiency: A Comparative Study.Qatar medical journal · 2022Article
- Whole-exome sequencing reveals insights into genetic susceptibility to Congenital Zika Syndrome.PLoS neglected tropical diseases · 2021Article
- Current investigations on clinical pharmacology and therapeutics of Glucose-6-phosphate dehydrogenase deficiency.Pharmacology & therapeutics · 2021Review
- G6PD deficiency, redox homeostasis, and viral infections: implications for SARS-CoV-2 (COVID-19).Free radical research · 2021Review
- Increased levels of pentraxins protein and cytokines bear good association in patients with severe dengue infection.Scientific reports · 2021Article
- Molecular characterization of G6PD mutations reveals the high frequency of G6PD Aures in the Lao Theung population.Malaria journal · 2021Article
- Review
- Impact of glucose-6-phosphate dehydrogenase deficiency on dengue infection in Myanmar children.PloS one · 2019Observational
- Antiviral activities of Schizonepeta tenuifolia Briq. against enterovirus 71 in vitro and in vivo.Scientific reports · 2017Article
- The GSK3/Shaggy-Like Kinase ASKα Contributes to Pattern-Triggered Immunity.Plant physiology · 2016Article
- Article
- Dengue virus type 2 (DENV2)-induced oxidative responses in monocytes from glucose-6-phosphate dehydrogenase (G6PD)-deficient and G6PD normal subjects.PLoS neglected tropical diseases · 2014Article
- Glucose-6-phosphate dehydrogenase (G6PD)-deficient epithelial cells are less tolerant to infection by Staphylococcus aureus.PloS one · 2013Article
- Inhibition of dengue virus entry and multiplication into monocytes using RNA interference.PLoS neglected tropical diseases · 2011Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The prevalence of glucose-6-phosphate dehydrogenase (G6PD) deficiency is high in Asia. An ex vivo study was conducted to elucidate the association of G6PD deficiency and dengue virus (DENV) infection when many Asian countries are hyper-endemic. Human monocytes from peripheral mononuclear cells collected from 12 G6PD-deficient patients and 24 age-matched controls were infected with one of two DENV serotype 2 (DENV-2) strains-the New Guinea C strain (from a case of dengue fever) or the 16681 strain (from a case of dengue hemorrhagic fever) with a multiplicity of infection of 0.1. The infectivity of DENV-2 in human monocytes was analyzed by flow cytometry. Experimental results indicated that the monocytes of G6PD-deficient patients exhibited a greater levels of infection with DENV-2 New Guinea C strain than did those in healthy controls [mean+/-SD:33.6%+/-3.5 (27.2% approximately 39.2%) vs 20.3%+/-6.2 (8.0% approximately 30.4%), P<0.01]. Similar observations were made of infection with the DENV-2 16681 strain [40.9%+/-3.9 (35.1% approximately 48.9%) vs 27.4%+/-7.1 (12.3% approximately 37.1%), P<0.01]. To our knowledge, this study demonstrates for the first time higher infection of human monocytes in G6PD patients with the dengue virus, which may be important in increasing epidemiological transmission and perhaps with the potential to develop more severe cases pathogenically.
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