ArticleBiology letters2008
Candidate gene microsatellite variation is associated with parasitism in wild bighorn sheep.
Article in Biology letters, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 118 citations in OpenAlex.
- Infectious disease as a driver of declines and extinctions.Cambridge prisms. Extinction · 2024Review
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- Genomic heterozygosity is associated with parasite abundance, but the effects are not mediated by host condition.Evolutionary ecology · 2023Article
- Coinfection patterns of two marine apicomplexans are not associated with genetic diversity of their polychaete host.The Journal of eukaryotic microbiology · 2023Article
- Functional immunogenetic variation, rather than local adaptation, predicts ectoparasite infection intensity in a model fish species.Molecular ecology · 2021Article
- Ecological interventions to prevent and manage zoonotic pathogen spillover.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Review
- Heterozygosity at neutral and immune loci is not associated with neonatal mortality due to microbial infection in Antarctic fur seals.Ecology and evolution · 2019Article
- Both candidate gene and neutral genetic diversity correlate with parasite resistance in female Mediterranean mouflon.BMC ecology · 2019Article
- Infection dynamics of gastrointestinal helminths in sympatric non-human primates, livestock and wild ruminants in Kenya.PloS one · 2019Article
- Host heterozygosity and genotype rarity affect viral dynamics in an avian subspecies complex.Scientific reports · 2017Article
- MYD88 and functionally related genes are associated with multiple infections in a model population of Kenyan village dogs.Molecular biology reports · 2016Article
- Local effects drive heterozygosity-fitness correlations in an outcrossing long-lived tree.Proceedings. Biological sciences · 2015Article
- Genome-wide scan of gastrointestinal nematode resistance in closed Angus population selected for minimized influence of MHC.PloS one · 2015Article
- AFLPs and mitochondrial haplotypes reveal local adaptation to extreme thermal environments in a freshwater gastropod.PloS one · 2014Article
- Environmental attributes to respiratory diseases of small ruminants.Veterinary medicine international · 2014Review
- Genetic susceptibility to infectious disease in East African Shorthorn Zebu: a genome-wide analysis of the effect of heterozygosity and exotic introgression.BMC evolutionary biology · 2013Article
- Sex-specific correlations of individual heterozygosity, parasite load, and scalation asymmetry in a sexually dichromatic lizard.PloS one · 2013Article
- Applicability of major histocompatibility complex DRB1 alleles as markers to detect vertebrate hybridization: a case study from Iberian ibex × domestic goat in southern Spain.Acta veterinaria Scandinavica · 2012Article
- Genetic diversity at neutral and adaptive loci determines individual fitness in a long-lived territorial bird.Proceedings. Biological sciences · 2012Article
- The effect and relative importance of neutral genetic diversity for predicting parasitism varies across parasite taxa.PloS one · 2012Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The loss of genetic variation in host populations is thought to increase host susceptibility to parasites. However, few data exist to test this hypothesis in natural populations. Bighorn sheep (Ovis canadensis) populations occasionally suffer disease-induced population declines, allowing us to test for the associations between reduced genetic variation and parasitism in this species. Here, we show that individual mean heterozygosity for 15 microsatellite loci is associated with lungworm abundance (Protostrongylus spp.) in a small, recently bottlenecked population of bighorn sheep (linear regression, r2=0.339, p=0.007). This association remains significant for seven microsatellites located in genes (p=0.010), but not for eight neutral microsatellites (p=0.306). Furthermore, heterozygotes at three of four microsatellites located within disease-related genes had lower lungworm burdens. This study corroborates theoretical findings that increased parasitism and disease may be a consequence of reduced heterozygosity in wild populations, and that certain individual loci influence parasite resistance. The results illustrate the usefulness of using genomic information, strong candidate genes and non-invasive sampling for monitoring both genetic variation and fitness-related traits, such as parasite resistance, in natural populations.
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