ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2008
Genetics of the musculoskeletal system: a pleiotropic approach.
Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 2 syntheses or guidelines pooled it, 115 citations in OpenAlex.
- Risk factors of stroke-related sarcopenia: a systematic review and meta-analysis.Frontiers in aging · 2025Pooled it
- Sarcopenia as a Risk Factor for Future Hip Fracture: A Meta-Analysis of Prospective Cohort Studies.The journal of nutrition, health & aging · 2021Pooled it
- Prevalence of Sarcopenia and Its Relationship with Sites of Fragility Fractures in Elderly Chinese Men and Women.PloS one · 2015Trial
- Multivariate genetic analysis reveals three distinct pathological dimensions in musculoskeletal disorders.Nature communications · 2026Article
- Research progress on sarcopenia in the musculoskeletal system.Bone research · 2025Review
- Deciphering the genetic interconnection between sarcopenia and osteoporosis: SCD1.Journal of bone and mineral metabolism · 2025Article
- Association between sarcopenia and osteoporosis: the cross-sectional study from NHANES 1999-2020 and a bi-directions Mendelian randomization study.Frontiers in endocrinology · 2024Article
- Structural lesions and transcriptomic specializations shape gradient perturbations in Wilson disease.Brain communications · 2024Article
- Article
- A Comprehensive Review of Modifiable Cardiovascular Risk Factors and Genetic Influences in Dementia Prevention.Cureus · 2023Review
- Targeting Sarcopenia as an Objective Clinical Outcome in the Care of Children with Spinal Cord-Related Paralysis: A Clinician's View.Children (Basel, Switzerland) · 2023Review
- wnt16 regulates spine and muscle morphogenesis through parallel signals from notochord and dermomyotome.PLoS genetics · 2022Article
- Associations of the Alpha-Actinin Three Genotype with Bone and Muscle Mass Loss among Middle-Aged and Older Adults.Journal of clinical medicine · 2022Article
- Relationship between oseteoporosis with fatty infiltration of paraspinal muscles based on QCT examination.Journal of bone and mineral metabolism · 2022Article
- Femur Length is Correlated with Isometric Quadriceps Strength in Post-Operative Patients.International journal of sports physical therapy · 2022Article
- Interactive effect of sarcopenia and falls on vertebral osteoporotic fracture in patients with rheumatoid arthritis.Archives of osteoporosis · 2021Article
- Body composition and bone status in relation to microvascular damage in systemic sclerosis patients.Journal of endocrinological investigation · 2021Article
- The genetic architecture of appendicular lean mass characterized by association analysis in the UK Biobank study.Communications biology · 2020Article
- Bone-Muscle Mutual Interactions.Current osteoporosis reports · 2020Review
- Bone Mass Loss and Sarcopenia in Ecuadorian Patients.Journal of aging research · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The risk of osteoporotic fracture can be viewed as a function of loading conditions and the ability of the bone to withstand the load. Skeletal loads are dominated by muscle action. Recently, it has become clear that bone and muscle share genetic determinants. Involution of the musculoskeletal system manifests as bone loss (osteoporosis) and muscle wasting (sarcopenia). Therefore, the consideration of pleiotropy is an important aspect in the study of the genetics of osteoporosis and sarcopenia. This Perspective will provide the evidence for a shared genetic influence on bone and muscle. We will start with an overview of accumulating evidence that physical exercise produces effects on the adult skeleton, seeking to unravel some of the contradictory findings published thus far. We will provide indications that there are pleiotropic relationships between bone structure/mass and muscle mass/function. Finally, we will offer some insights and practical recommendations as to the value of studying shared genetic factors and will explore possible directions for future research. We consider several related questions that together comprise the general paradigm of bone responses to mechanical loading and the relationship between muscle strength and bone parameters, including the genetic factors that modulate these responses. We believe that further progress in understanding the common genetic etiology of osteoporosis and sarcopenia will provide valuable insight into important biological underpinnings for both conditions and may translate into new approaches to reduce the burdens of both conditions through improved diagnosis, prevention, and early targeted treatment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.