ArticleAdvances in experimental medicine and biology2007
The role of cyclic nucleotides in axon guidance.
Article in Advances in experimental medicine and biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 36 citations in OpenAlex.
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- Serotonergic stimulation induces nerve growth and promotes visual learning via posterior eye grafts in a vertebrate model of induced sensory plasticity.NPJ Regenerative medicine · 2017Article
- Intracellular calcium and cyclic nucleotide levels modulate neurite guidance by microtopographical substrate features.Journal of biomedical materials research. Part A · 2016Article
- Structure-based discovery of highly selective phosphodiesterase-9A inhibitors and implications for inhibitor design.Journal of medicinal chemistry · 2012Article
- Improved molecular toolkit for cAMP studies in live cells.BMC research notes · 2011Article
- Spatial phosphoprotein profiling reveals a compartmentalized extracellular signal-regulated kinase switch governing neurite growth and retraction.The Journal of biological chemistry · 2011Article
- Phosphorylation of STEF/Tiam2 by protein kinase A is critical for Rac1 activation and neurite outgrowth in dibutyryl cAMP-treated PC12D cells.Molecular biology of the cell · 2011Article
- Nitric oxide synthase regulates morphogenesis of zebrafish spinal cord motoneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- The calmodulin-stimulated adenylate cyclase ADCY8 sets the sensitivity of zebrafish retinal axons to midline repellents and is required for normal midline crossing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Insight into binding of phosphodiesterase-9A selective inhibitors by crystal structures and mutagenesis.Journal of medicinal chemistry · 2010Article
- The growth cone: an integrator of unique cues into refined axon guidance.F1000 biology reports · 2009Article
- Refolding and kinetic characterization of the phosphodiesterase-8A catalytic domain.Protein expression and purification · 2009Article
- Kinetic and structural studies of phosphodiesterase-8A and implication on the inhibitor selectivity.Biochemistry · 2008Article
- Ena/VASP: proteins at the tip of the nervous system.Current opinion in neurobiology · 2008Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
During the formation of the nervous system, axonal growth cones navigate through the complex environment of the developing embryo to innervate their targets. Growth cones achieve this formidable feat by responding to attractive or repulsive guidance cues expressed at specific points along the trajectory of their growth, which impart the directional information required for accurate pathfinding. While much is known about guidance molecules and their receptors, many questions remain unanswered. Which signal transduction pathways are activated within the growth cone after encountering a guidance cue? How is this related to rearrangement of the growth cone cytoskeleton? Do different cues use different signal transduction pathways? This chapter will review some of the work that has addressed these fundamental questions, with a specific focus on the role of the cyclic nucleotides, cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), in axon guidance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.