ArticleBritish journal of cancer2008
Cortactin expression predicts poor survival in laryngeal carcinoma.
Article in British journal of cancer, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Oncogene amplification of CCND1 via extrachromosomal DNA impacts overall survival in head and neck squamous cell carcinoma.Discover oncology · 2026Article
- Review
- Laryngeal Cancer in the Modern Era: Evolving Trends in Diagnosis, Treatment, and Survival Outcomes.Journal of clinical medicine · 2025Review
- Mathematical Modelling of Cervical Precancerous Lesion Grade Risk Scores: Linear Regression Analysis of Cellular Protein Biomarkers and Human PapillomavirusDiagnostics (Basel, Switzerland) · 2023Article
- Article
- PRMT5 promotes cancer cell migration and invasion through the E2F pathway.Cell death & disease · 2020Article
- EPHB2 carried on small extracellular vesicles induces tumor angiogenesis via activation of ephrin reverse signaling.JCI insight · 2019Article
- The chromosome 11q13.3 amplification associated lymph node metastasis is driven by miR-548k through modulating tumor microenvironment.Molecular cancer · 2018Article
- miR-182 suppresses invadopodia formation and metastasis in non-small cell lung cancer by targeting cortactin gene.Journal of experimental & clinical cancer research : CR · 2018Article
- Article
- Expression and significance of cortactin and HDAC6 in human prostatic foamy gland carcinoma.International journal of experimental pathology · 2015Article
- Movers and shakers: cell cytoskeleton in cancer metastasis.British journal of pharmacology · 2014Review
- Differential Tks5 isoform expression contributes to metastatic invasion of lung adenocarcinoma.Genes & development · 2013Article
- Neutrophils Activate Tumoral CORTACTIN to Enhance Progression of Orohypopharynx Carcinoma.Frontiers in immunology · 2013Article
- An eQTL-based method identifies CTTN and ZMAT3 as pemetrexed susceptibility markers.Human molecular genetics · 2012Article
- Comprehensive exon array data processing method for quantitative analysis of alternative spliced variants.Nucleic acids research · 2011Article
- Nucleating actin for invasion.Nature reviews. Cancer · 2011Review
- Recently identified biomarkers that promote lymph node metastasis in head and neck squamous cell carcinoma.Cancers · 2011Article
- Cortactin modulates RhoA activation and expression of Cip/Kip cyclin-dependent kinase inhibitors to promote cell cycle progression in 11q13-amplified head and neck squamous cell carcinoma cells.Molecular and cellular biology · 2010Article
- Strategies to promote translational research within the European Organisation for Research and Treatment of Cancer (EORTC) Head and Neck Cancer Group: a report from the Translational Research Subcommittee.Annals of oncology : official journal of the European Society for Medical Oncology · 2010Review
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Authors and funding
7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Amplification of the 11q13 region is one of the most frequent aberrations in squamous cell carcinomas of the head and neck region (HNSCC). Amplification of 11q13 has been shown to correlate with the presence of lymph node metastases and decreased survival. The 11q13.3 amplicon carries numerous genes including cyclin D1 and cortactin. Recently, we reported that FADD becomes overexpressed upon amplification and that FADD protein expression predicts for lymph node positivity and disease-specific mortality. However, the gene within the 11q13.3 amplicon responsible for this correlation is yet to be identified. In this paper, we compared, using immunohistochemical analysis for cyclin D1, FADD and cortactin in a series of 106 laryngeal carcinomas which gene correlates best with lymph node metastases and increased disease-specific mortality. Univariate Cox regression analysis revealed that high expression of cyclin D1 (P=0.016), FADD (P=0.003) and cortactin (P=0.0006) predict for increased risk to disease-specific mortality. Multivariate Cox analysis revealed that only high cortactin expression correlates with disease-specific mortality independent of cyclin D1 and/or FADD. Of genes located in the 11q13 amplicon, cortactin expression is the best predictor for shorter disease-specific survival in late stage laryngeal carcinomas.
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