ArticleAntimicrobial agents and chemotherapy2008
Different pathways to acquiring resistance genes illustrated by the recent evolution of IncW plasmids.
Article in Antimicrobial agents and chemotherapy, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Phospholipid-independent biogenesis and function of the RP4 conjugation pilus.Nature communications · 2026Article
- PlasAnn: a curated plasmid-specific database and annotation pipeline for standardized gene and function analysis.Nucleic acids research · 2026Article
- Selective shifts in mobile antibiotic resistance genes under carbamazepine exposure in wastewater microbiomes.ISME communications · 2026Article
- Encounter rates and engagement times limit the transmission of conjugative plasmids.PLoS genetics · 2025Article
- Applying rearrangement distances to enable plasmid epidemiology with pling.Microbial genomics · 2024Article
- Cobalt complexes modulate plasmid conjugation in Escherichia coli and Klebsiella pneumoniae.Scientific reports · 2024Article
- Mechanism of antibacterial resistance, strategies and next-generation antimicrobials to contain antimicrobial resistance: a review.Frontiers in pharmacology · 2024Review
- Genomic epidemiology and heterogeneity ofEmerging microbes & infections · 2023Article
- Antimicrobial Resistance in Romania: Updates on Gram-Negative ESCAPE Pathogens in the Clinical, Veterinary, and Aquatic Sectors.International journal of molecular sciences · 2023Review
- Evolution of Plasmid Mobility: Origin and Fate of Conjugative and Nonconjugative Plasmids.Molecular biology and evolution · 2022Article
- Intra- and interpopulation transposition of mobile genetic elements driven by antibiotic selection.Nature ecology & evolution · 2022Article
- Article
- Evolution and implementation of One Health to control the dissemination of antibiotic-resistant bacteria and resistance genes: A review.Frontiers in cellular and infection microbiology · 2022Review
- Identification of a novel aminoglycosideFrontiers in microbiology · 2022Article
- Article
- ISmSphere · 2020Article
- Reconsidering plasmid maintenance factors for computational plasmid design.Computational and structural biotechnology journal · 2019Review
- Characterization and Bio-Typing of Multidrug Resistance Plasmids From UropathogenicFrontiers in microbiology · 2019Article
- Mobile Genetic Elements Associated with Antimicrobial Resistance.Clinical microbiology reviews · 2018Review
- DNA structure at the plasmid origin-of-transfer indicates its potential transfer range.Scientific reports · 2018Article
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8 authors.
Funding
Abstract
DNA sequence analysis of five IncW plasmids (R388, pSa, R7K, pIE321, and pIE522) demonstrated that they share a considerable portion of their genomes and allowed us to define the IncW backbone. Among these plasmids, the backbone is stable and seems to have diverged recently, since the overall identity among its members is higher than 95%. The only gene in which significant variation was observed was trwA; the changes in the coding sequence correlated with parallel changes in the corresponding TrwA binding sites at oriT, suggesting a functional connection between both sets of changes. The present IncW plasmid diversity is shaped by the acquisition of antibiotic resistance genes as a consequence of the pressure exerted by antibiotic usage. Sequence comparisons pinpointed the insertion events that differentiated the five plasmids analyzed. Of greatest interest is that a single acquisition of a class I integron platform, into which different gene cassettes were later incorporated, gave rise to plasmids R388, pIE522, and pSa, while plasmids R7K and pIE321 do not contain the integron platform and arose in the antibiotic world because of the insertion of several antibiotic resistance transposons.
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