ArticleDiabetes care2008
Glucose and insulin measurements from the oral glucose tolerance test and mortality prediction.
Article in Diabetes care, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 46 citations in OpenAlex.
- Article
- Postprandial 2-h glucose tolerance is associated with diabetes diagnosis, diabetes mortality, and cardiovascular mortality.Scientific reports · 2025Article
- Effect of self-paced sprint interval training and low-volume HIIT on cardiorespiratory fitness: the role of heart rate and power output.Frontiers in physiology · 2025Article
- Body Mass Index and Diabetes Incidence Across the Adult Lifespan: The Baltimore Longitudinal Study of Aging.Journal of the Endocrine Society · 2024Article
- Nonlinear modeling of oral glucose tolerance test response to evaluate associations with aging outcomes.PloS one · 2024Article
- Changes in tear glucose and insulin concentrations following an oral glucose tolerance test.Clinical & experimental optometry · 2023Article
- Multisystem physiological perspective of human frailty and its modulation by physical activity.Physiological reviews · 2023Review
- Rare Sugar Metabolism and Impact on Insulin Sensitivity along the Gut-Liver-Muscle Axis In Vitro.Nutrients · 2023Article
- Neuroimaging and clinical characteristics of cognitive migration in community-dwelling older adults.NeuroImage. Clinical · 2022Article
- Epidemiology of Isolated Impaired Glucose Tolerance Among Adults Aged Above 50 Years in Rural China.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- The Relationship of Lean Body Mass With Aging to the Development of Diabetes.Journal of the Endocrine Society · 2020Article
- Blood Metabolite Signature of Metabolic Syndrome Implicates Alterations in Amino Acid Metabolism: Findings from the Baltimore Longitudinal Study of Aging (BLSA) and the Tsuruoka Metabolomics Cohort Study (TMCS).International journal of molecular sciences · 2020Article
- Sex Differences in the Prevalence of and Risk Factors for Abnormal Glucose Regulation in Adults Aged 50 Years or Older With Normal Fasting Plasma Glucose Levels.Frontiers in endocrinology · 2020Article
- Age-Related Changes in Glucose Metabolism, Hyperglycemia, and Cardiovascular Risk.Circulation research · 2018Review
- Altered Plasma Amino Acids and Lipids Associated With Abnormal Glucose Metabolism and Insulin Resistance in Older Adults.The Journal of clinical endocrinology and metabolism · 2018Article
- Evidence for brain glucose dysregulation in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2018Article
- Metabolic characteristics of individuals at a high risk of type 2 diabetes - a comparative cross-sectional study.BMC endocrine disorders · 2017Article
- Interventions for Human Frailty: Physical Activity as a Model.Cold Spring Harbor perspectives in medicine · 2016Review
- Sex-specific differences in progressive glucose intolerance and hip geometry: the Baltimore Longitudinal Study of Aging.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015Article
- Atherosclerotic cardiovascular disease in older adults with diabetes mellitus.Clinics in geriatric medicine · 2015Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveTo verify what information from oral glucose tolerance tests (OGTTs) independently predicts mortality. RESEARCH DESIGN AND
methodsA total of 1,401 initially nondiabetic participants from the Baltimore Longitudinal Study of Aging aged 17-95 years underwent one or more OGTTs (median 2, range 1-8), with insulin and glucose measurements taken every 20 min over the course of 2 h included in this study. Proportional hazards using the longitudinally collected data and Bayesian model averaging were used to examine the association of OGTT measurements individually and grouped with mortality, adjusting for covariates.
resultsParticipants were followed for a median 20.3 years (range 0.5-40). The first-hour OGTT glucose and insulin levels increased only modestly with age, whereas levels during the second hour increased 4% per decade. Individually, 100- and 120-min glucose measures and fasting and 100-min insulin levels were all independent predictors of mortality. When all measures were considered together, only higher 120-min glucose was a significant independent risk factor for mortality.
conclusionThe steeper rise with age of the OGTT 2-h glucose values and the prognostic primacy of the 120-min glucose value for mortality is consistent with previous reports and suggests the value of using the OGTT in clinical practice.
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