ArticleNucleic acids research2008
Identification of CUG-BP1/EDEN-BP target mRNAs in Xenopus tropicalis.
Article in Nucleic acids research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 48 citations in OpenAlex.
- Ythdf mCell reports · 2020Article
- Increased nuclear but not cytoplasmic activities of CELF1 protein leads to muscle wasting.Human molecular genetics · 2020Article
- Profiling of rotavirus 3'UTR-binding proteins reveals the ATP synthase subunit ATP5B as a host factor that supports late-stage virus replication.The Journal of biological chemistry · 2019Article
- Post-translational regulation of the maternal-to-zygotic transition.Cellular and molecular life sciences : CMLS · 2018Review
- The hepatitis C viral nonstructural protein 5A stabilizes growth-regulatory human transcripts.Nucleic acids research · 2018Article
- Identification of CELF1 RNA targets by CLIP-seq in human HeLa cells.Genomics data · 2016Article
- Identification of Targets of CUG-BP, Elav-Like Family Member 1 (CELF1) Regulation in Embryonic Heart Muscle.PloS one · 2016Article
- The Maternal-to-Zygotic Transition During Vertebrate Development: A Model for Reprogramming.Current topics in developmental biology · 2015Review
- Alternative polyadenylation regulates CELF1/CUGBP1 target transcripts following T cell activation.Gene · 2014Article
- A genome-wide survey of maternal and embryonic transcripts during Xenopus tropicalis development.BMC genomics · 2013Article
- Celf1 is required for formation of endoderm-derived organs in zebrafish.International journal of molecular sciences · 2013Article
- Structural insights into the targeting of mRNA GU-rich elements by the three RRMs of CELF1.Nucleic acids research · 2013Article
- Position-dependent and neuron-specific splicing regulation by the CELF family RNA-binding protein UNC-75 in Caenorhabditis elegans.Nucleic acids research · 2013Article
- Translational control by changes in poly(A) tail length: recycling mRNAs.Nature structural & molecular biology · 2012Review
- Genome-wide analysis of the maternal-to-zygotic transition in Drosophila primordial germ cells.Genome biology · 2012Article
- Sequence determinants for the tandem recognition of UGU and CUG rich RNA elements by the two N--terminal RRMs of CELF1.Nucleic acids research · 2011Article
- Coordinate regulation of mRNA decay networks by GU-rich elements and CELF1.Current opinion in genetics & development · 2011Review
- Aging of Xenopus tropicalis eggs leads to deadenylation of a specific set of maternal mRNAs and loss of developmental potential.PloS one · 2010Article
- Structural insights into RNA recognition by the alternate-splicing regulator CUG-binding protein 1.Structure (London, England : 1993) · 2010Article
- Analysis of CUGBP1 targets identifies GU-repeat sequences that mediate rapid mRNA decay.Molecular and cellular biology · 2010Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The early development of many animals relies on the posttranscriptional regulations of maternally stored mRNAs. In particular, the translation of maternal mRNAs is tightly controlled during oocyte maturation and early mitotic cycles in Xenopus. The Embryonic Deadenylation ElemeNt (EDEN) and its associated protein EDEN-BP are known to trigger deadenylation and translational silencing to several mRNAs bearing an EDEN. This Xenopus RNA-binding protein is an ortholog of the human protein CUG-BP1/CELF1. Five mRNAs, encoding cell cycle regulators and a protein involved in the notch pathway, have been identified as being deadenylated by EDEN/EDEN-BP. To identify new EDEN-BP targets, we immunoprecipitated EDEN-BP/mRNA complexes from Xenopus tropicalis egg extracts. We identified 153 mRNAs as new binding targets for EDEN-BP using microarrays. Sequence analyses of the 3' untranslated regions of the newly identified EDEN-BP targets reveal an enrichment in putative EDEN sequences. EDEN-BP binding to a subset of the targets was confirmed both in vitro and in vivo. Among the newly identified targets, Cdk1, a key player of oocyte maturation and cell cycle progression, is specifically targeted by its 3' UTR for an EDEN-BP-dependent deadenylation after fertilization.
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