ReviewJournal of cellular and molecular medicine
Applications of SELDI-MS technology in oncology.
Review in Journal of cellular and molecular medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Article
- Review
- Screening of serum protein biomarkers in hemorrhagic cerebral infarction by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS) technology.Annals of translational medicine · 2020Article
- Gingival Crevicular Fluid Peptidome Profiling in Healthy and in Periodontal Diseases.International journal of molecular sciences · 2020Review
- Article
- Urinary proteomics and metabolomics studies to monitor bladder health and urological diseases.BMC urology · 2016Review
- Article
- Enriched sera protein profiling for detection of non-small cell lung cancer biomarkers.Proteome science · 2011Article
- The application of a three-step proteome analysis for identification of new biomarkers of pancreatic cancer.International journal of proteomics · 2011Article
- The application of SELDI-TOF-MS in clinical diagnosis of cancers.Journal of biomedicine & biotechnology · 2011Review
- Protein expression profiles distinguish between experimental invasive pulmonary aspergillosis and Pseudomonas pneumonia.Proteomics · 2010Article
- Association of serum amyloid A protein and peptide fragments with prognosis in renal cancer.British journal of cancer · 2010Article
- Imaging of meningioma progression by matrix-assisted laser desorption ionization time-of-flight mass spectrometry.Analytical chemistry · 2010Article
- Identification of novel diagnostic serum biomarkers for Chagas' disease in asymptomatic subjects by mass spectrometric profiling.Journal of clinical microbiology · 2010Article
- Challenges for biomarker discovery in body fluids using SELDI-TOF-MS.Journal of biomedicine & biotechnology · 2010Review
- Identification of a beta-casein-like peptide in breast nipple aspirate fluid that is associated with breast cancer.Biomarkers in medicine · 2009Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Considerable interest, speculation and controversy have been generated utilising surface-enhanced laser desorption/ionization in conjunction with mass spectrometry (SELDI-MS) for the diagnosis, prognosis and therapeutic monitoring of cancer and offers an attractive approach to cancer biomarker discovery from tissues and biological fluids. This technology utilises a combination of mass spectrometry and chromatography to facilitate protein profiling of complex biological mixtures. Compared to some other more traditional proteomic platforms, such as 2D polyacrylamide gel electrophoresis, it has a high-throughput capability and can resolve low-mass proteins. However, a considerable number of challenging issues related to the design of studies, including reproducibility, sensitivity, specificity, variation in sample collection, processing and storage, have been reported as problematic with this technology; albeit some of these concerns could perhaps also be lauded against other proteomic approaches that have attempted to address complex protein mixtures, such as plasma. Applications, successes and limitations of SELDI-MS in both clinical and basic science arenas will be reviewed in this article.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.