ArticleJournal of cellular and molecular medicine2008
Expression of survivin protein in pterygium and relationship with oxidative DNA damage.
Article in Journal of cellular and molecular medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 39 citations in OpenAlex.
- The Role of the Stromal Extracellular Matrix in the Development of Pterygium Pathology: An Update.Journal of clinical medicine · 2021Review
- Relative gene expression analysis of human pterygium tissues and UV radiation-evoked gene expression patterns in corneal and conjunctival cells.Experimental eye research · 2020Article
- A novel role for Livin in the response to ultraviolet B radiation and pterygium development.International journal of molecular medicine · 2020Article
- Human papillomavirus infection and ocular surface disease (Review).International journal of oncology · 2019Review
- Vitamin D and vitamin D receptor in patients with ophthalmic pterygium.European journal of histochemistry : EJH · 2017Article
- Aberrant expression of genes and proteins in pterygium and their implications in the pathogenesis.International journal of ophthalmology · 2017Review
- HMGB1 in the pathogenesis of ultraviolet-induced ocular surface inflammation.Cell death & disease · 2015Article
- Peroxiredoxin I and II in human eyes: cellular distribution and association with pterygium and DNA damage.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2014Article
- Induction of endothelial RAGE expression in pterygium.Molecular vision · 2014Article
- EphB4 expression in pterygium is associated with microvessel density.International journal of clinical and experimental medicine · 2014Article
- Autonomous inhibition of apoptosis correlates with responsiveness of colon carcinoma cell lines to ciglitazone.PloS one · 2014Article
- Association of human papilloma virus with pterygia and ocular-surface squamous neoplasia.Eye (London, England) · 2012Review
- Survivin and p53 expression in primary and recurrent pterygium in Chinese patients.International journal of ophthalmology · 2011Article
- Relationship between the expression of cyclooxygenase-2 and survivin in primary pterygium.Molecular vision · 2009Article
- Genomic instability and eye diseases.Advances in ophthalmology practice and researchReview
Corrections and comments
- Erratum issued
Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ultraviolet radiation is known to cause oxidative DNA damage and is thought to be a major factor implicated in the pathogenesis of pterygium. Among all the photo-oxidative DNA products, the 8-hydroxydeoxyguanosine (8-OHdG) is regarded a sensitive and stable biomarker for evaluating the degree of DNA damage. The protein p53 is a major cell stress regulator that acts to integrate signals from a wide range of cellular stresses. UV radiation has a carcinogenic effect resulting in DNA damaged cells with loss of normal growth control. This assumption is supported by the association between UV-B exposure and activation of survivin, a member of the inhibitor of apoptosis protein family (IAP), highly up-regulated in almost all types of human malignancy. In this study we demonstrate, for the first time in pterygium, the immunohistochemical presence of survivin, and investigate the correlation between survivin, p53 and 8-OHdG. Our results demonstrate that oxidative stress could lead to a significant activation of survivin expression, suggesting that this might be an important event in the development of pterygium, inducing and supporting a hyperproliferative condition. Survivin expression in pterygium would counteract UV-B-induced apoptosis and would cooperate with loss of p53. The co-operation between survivin and functional loss of p53 might provide a general mechanism for aberrant inhibition of apoptosis that could be responsible for the development of pterygium and its possible progression to neoplasia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.