ArticleThe Plant journal : for cell and molecular biology2008
Metabolite annotations based on the integration of mass spectral information.
Article in The Plant journal : for cell and molecular biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers.
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109 citing papers in PubMed.
- SlBES1-mediated brassinosteroid signaling suppresses flavonoid biosynthesis in tomato fruit.Plant communications · 2025Article
- Development of phytochemical genomics: From decoding metabolome to functional genomics and biotechnology of plant metabolism.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2025Review
- Increase of secondary metabolites in sweet basil (Ocimum basilicum L.) leaves by exposure to NScientific reports · 2024Article
- RefMetaPlant: a reference metabolome database for plants across five major phyla.Nucleic acids research · 2024Article
- Metabolomics Study of the Effect of Transcription Factor NOR-like1 on Flavonoids in Tomato at Different Stages of Maturity Using UPLC-MS/MS.Foods (Basel, Switzerland) · 2023Article
- Recent advances in steroidal glycoalkaloid biosynthesis in the genusPlant biotechnology (Tokyo, Japan) · 2023Article
- Downregulation of a cluster of genes encoding nitrate transporter 1/peptide transporter family proteins in tomato with a mutated JRE4 transcription factor.Plant biotechnology (Tokyo, Japan) · 2023Article
- TheInternational journal of molecular sciences · 2023Article
- Genetics and breeding of phenolic content in tomato, eggplant and pepper fruits.Frontiers in plant science · 2023Review
- A Jasmonate-Responsive ERF Transcription Factor Regulates Steroidal Glycoalkaloid Biosynthesis Genes in Eggplant.Plants (Basel, Switzerland) · 2022Article
- Content of Two Major Steroidal Glycoalkaloids in Tomato (Plants (Basel, Switzerland) · 2022Article
- Steroidal alkaloid biosynthesis is coordinately regulated and differs among tomatoes in the red-fruited clade.The plant genome · 2022Article
- Omics Profiles of Non-transgenic Scion Grafted on Transgenic RdDM Rootstock.Food safety (Tokyo, Japan) · 2022Article
- Effect of Transgenic Rootstock Grafting on the Omics Profiles in Tomato.Food safety (Tokyo, Japan) · 2021Article
- Metabolic engineering of tomato fruit enriched in L-DOPA.Metabolic engineering · 2021Article
- TOMATOMET: A metabolome database consists of 7118 accurate mass values detected in mature fruits of 25 tomato cultivars.Plant direct · 2021Article
- The GORKY glycoalkaloid transporter is indispensable for preventing tomato bitterness.Nature plants · 2021Article
- Diverting tyrosine: Data from untargeted metabolic analysis of tomato fruit accumulating L-DOPA.Data in brief · 2021Article
- Metabolome analysis revealed that soybean-Aspergillus oryzae interaction induced dynamic metabolic and daidzein prenylation changes.PloS one · 2021Article
- Analysis of wild tomato introgression lines elucidates the genetic basis of transcriptome and metabolome variation underlying fruit traits and pathogen response.Nature genetics · 2020Article
49 more citing papers are in PubMed but not listed here.
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13 authors.
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Abstract
A large number of metabolites are found in each plant, most of which have not yet been identified. Development of a methodology is required to deal systematically with unknown metabolites, and to elucidate their biological roles in an integrated 'omics' framework. Here we report the development of a 'metabolite annotation' procedure. The metabolite annotation is a process by which structures and functions are inferred for metabolites. Tomato (Solanum lycopersicum cv. Micro-Tom) was used as a model for this study using LC-FTICR-MS. Collected mass spectral features, together with predicted molecular formulae and putative structures, were provided as metabolite annotations for 869 metabolites. Comparison with public databases suggests that 494 metabolites are novel. A grading system was introduced to describe the evidence supporting the annotations. Based on the comprehensive characterization of tomato fruit metabolites, we identified chemical building blocks that are frequently found in tomato fruit tissues, and predicted novel metabolic pathways for flavonoids and glycoalkaloids. These results demonstrate that metabolite annotation facilitates the systematic analysis of unknown metabolites and biological interpretation of their relationships, which provide a basis for integrating metabolite information into the system-level study of plant biology.
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