ReviewImmunologic research2008
Extrinsic and intrinsic regulation of early natural killer cell development.
Review in Immunologic research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Comprehensive snapshots of natural killer cells functions, signaling, molecular mechanisms and clinical utilization.Signal transduction and targeted therapy · 2024Review
- Dual Activity of Type III PI3K Kinase Vps34 is Critical for NK Cell Development and Senescence.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- The War Is on: The Immune System against Glioblastoma-How Can NK Cells Drive This Battle?Biomedicines · 2022Review
- Natural Killer Cells in the Malignant Niche of Multiple Myeloma.Frontiers in immunology · 2021Review
- Human signal transducer and activator of transcription 5b (STAT5b) mutation causes dysregulated human natural killer cell maturation and impaired lytic function.The Journal of allergy and clinical immunology · 2020Article
- On the Way to Become a Natural Killer Cell.Frontiers in immunology · 2019Review
- Developmental and Functional Control of Natural Killer Cells by Cytokines.Frontiers in immunology · 2017Review
- Transcription factor Runx3 regulates interleukin-15-dependent natural killer cell activation.Molecular and cellular biology · 2014Article
- Location and cellular stages of natural killer cell development.Trends in immunology · 2013Review
- Epigenetic control of natural killer cell maturation by histone H2A deubiquitinase, MYSM1.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Molecular mechanisms influencing NK cell development: implications for NK cell malignancies.American journal of blood research · 2011Article
- Reprogramming of T cells to natural killer-like cells upon Bcl11b deletion.Science (New York, N.Y.) · 2010Article
- Multiple hats for natural killers.Current opinion in immunology · 2010Review
- Nfil3/E4bp4 is required for the development and maturation of NK cells in vivo.The Journal of experimental medicine · 2009Article
- The basic leucine zipper transcription factor E4BP4 is essential for natural killer cell development.Nature immunology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Natural killer (NK) cells are lymphocytes that play a critical role in both adaptive and innate immune responses. These cells develop from multipotent progenitors in the embryonic thymus and neonatal or adult bone marrow and recent evidence suggests that a subset of these cells may develop in the thymus. Thymus- and bone marrow-derived NK cells have unique phenotypes and functional abilities supporting the hypothesis that the microenvironment dictates the outcome of NK cell development. A detailed understanding of the mechanisms controlling this developmental program will be required to determine how alterations in NK cell development lead to disease and to determine how to harness this developmental program for therapeutic purposes. In this review, we discuss some of the known extrinsic stromal-cell derived factors and cell intrinsic transcription factors that function in guiding NK cell development.
Indexed as
Identifiers
18266115What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.