Evidence map›Paper›PMID 18265987›Full record

ArticleWorld journal of urology2008

Protective effects of sildenafil administration on testicular torsion/detorsion damage in rats.

Azadeh Beheshtian, Amirali Hassanzadeh Salmasi, Seyedmehdi Payabvash, Saman Kiumehr, Behtash Ghazinezami, Sina Rahimpour, Seyed Mohammad Tavangar, Ahmad Reza Dehpour

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Article in World journal of urology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
7.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 105 citations in OpenAlex.

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  17. Effect of sildenafil citrate in nicotine-induced ischemia: An experimental study using a rat model.The Canadian journal of plastic surgery = Journal canadien de chirurgie plastique · 2013
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  18. Tadalafil significantly reduces ischemia reperfusion injury in skin island flaps.Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India · 2013
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Azadeh BeheshtianDepartment of Pharmacology, School of Medicine, Tehran University of Medical Sciences, PO Box 13145-784, Tehran, Iran.
Amirali Hassanzadeh Salmasi
Seyedmehdi Payabvash
Saman Kiumehr
Behtash Ghazinezami
Sina Rahimpour
Seyed Mohammad Tavangar
Ahmad Reza Dehpour
Tehran University of Medical Sciences · IRJohns Hopkins Medicine · USUniversity of California System · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWe assessed the effectiveness of sildenafil administration during ischemic period in a rat model of testicular torsion/detorsion (T/D). MATERIAL AND

methodsSprague-Dawley rats were divided into four groups (n = 10). In those animals that underwent T/D, right testes were rotated 720 degrees for 1 h. Base line group was for basal normal values. Sham operated group was served as a control group. T/D group underwent 1 h testicular torsion. Sildenafil group received sildenafil (0.7 mg/kg) intraperitoneally 30 min after initiation of ischemic period. For measurement of lipid peroxidation and antioxidant enzyme activities, right testes of five animals in each group were excised after 4-h reperfusion. Germ cell apoptosis indices were determined 24 h following detorsion in right testes of remaining five animals in each group.

resultsMalondialdehyde (MDA) levels in T/D group were significantly higher versus control and base line groups. Moreover, testicular MDA values in sildenafil group were significantly lower than T/D. There were also significant decreases in catalase and superxide dismutase activities in T/D group compared with control and base line groups. These values were significantly higher in sildenafil group versus T/D. Germ cell apoptosis indices were significantly higher in both groups that experienced T/D in comparison to control and base line groups; however, sildenafil treatment significantly reduced the apoptosis in sildenafil group compared with T/D group.

conclusionSildenafil administration during testicular torsion decreased ischemia/reperfusion cellular damage. The results of biochemical studies suggest that, reduction of oxidative stress by sildenafil may have a major role in its cytoprotective effects.

Indexed as

AnimalsApoptosisCatalaseDisease Models, AnimalMaleMalondialdehydeOxidative StressPiperazinesPurinesRatsRats, Sprague-DawleyRegional Blood FlowReperfusion InjurySildenafil CitrateSpermatic Cord TorsionSpermatozoaCatalaseMalondialdehydePiperazinesPurinesSildenafil CitrateSulfonesSuperoxide DismutaseVasodilator Agents

Identifiers

PMID18265987
OpenAlexW2028597443

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.