ArticleProceedings of the National Academy of Sciences of the United States of America1991
Involvement of ras p21 protein in signal-transduction pathways from interleukin 2, interleukin 3, and granulocyte/macrophage colony-stimulating factor, but not from interleukin 4.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
69 citing papers in PubMed, 348 citations in OpenAlex.
- Review
- Guanfacine treatment improves ADHD phenotypes of impulsivity and hyperactivity in a neurofibromatosis type 1 mouse model.Journal of neurodevelopmental disorders · 2020Article
- Regulation of T-Cell Signaling by Post-Translational Modifications in Autoimmune Disease.International journal of molecular sciences · 2018Review
- Management of Two Juvenile Myelomonocytic Leukemia Patients According to Clinical and Genetic Features.Turkish journal of haematology : official journal of Turkish Society of Haematology · 2015Article
- Hyperactive Ras/MAPK signaling is critical for tibial nonunion fracture in neurofibromin-deficient mice.Human molecular genetics · 2013Article
- Juvenile myelomonocytic leukemia: epidemiology, etiopathogenesis, diagnosis, and management considerations.Paediatric drugs · 2010Review
- Combinatorial Signal Transduction Responses Mediated by Interleukin-2 and -4 Receptors in a Helper TCellular and molecular bioengineering · 2008Article
- The amino-terminal B-Raf-specific region mediates calcium-dependent homo- and hetero-dimerization of Raf.The EMBO journal · 2006Article
- Ral is both necessary and sufficient for the inhibition of myeloid differentiation mediated by Ras.Molecular and cellular biology · 2006Article
- Article
- Distinct mechanisms determine the patterns of differential activation of H-Ras, N-Ras, K-Ras 4B, and M-Ras by receptors for growth factors or antigen.Molecular and cellular biology · 2004Article
- Article
- JAKs, STATs and Src kinases in hematopoiesis.Oncogene · 2002Review
- A novel potential effector of M-Ras and p21 Ras negatively regulates p21 Ras-mediated gene induction and cell growth.Oncogene · 2001Article
- IL-3 signaling and the role of Src kinases, JAKs and STATs: a covert liaison unveiled.Oncogene · 2000Review
- Involvement of Shc and Cbl-PI 3-kinase in Lyn-dependent proliferative signaling pathways for G-CSF.Oncogene · 2000Article
- Activation of the Ras/mitogen-activated protein kinase pathway by kinase-defective epidermal growth factor receptors results in cell survival but not proliferation.Molecular and cellular biology · 1998Article
- Evidence implicating Gfi-1 and Pim-1 in pre-T-cell differentiation steps associated with beta-selection.The EMBO journal · 1998Article
- Nf1 regulates hematopoietic progenitor cell growth and ras signaling in response to multiple cytokines.The Journal of experimental medicine · 1998Article
- Ras activity late in G1 phase required for p27kip1 downregulation, passage through the restriction point, and entry into S phase in growth factor-stimulated NIH 3T3 fibroblasts.Molecular and cellular biology · 1997Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The protooncogene ras acts as a component of signal-transduction networks in many kinds of cells. The ras gene product (p21) is a GTP-binding protein, and the activity of the protein is regulated by bound GDP/GTP. Recent studies have shown that a certain class of growth factors stimulates the formation of active p21-GTP complexes in fibroblasts and that oncogene products with enhanced tyrosine kinase activities have a similar effect on ras p21. We have measured the ratio of active GTP-bound p21 to total p21 in several lymphoid and myeloid cell lines in order to understand the role of ras in the proliferation of these cells. Interleukin 2 (IL-2), IL-3, and granulocyte/macrophage colony-stimulating factor (GM-CSF) enhance the formation of the active p21.GTP, whereas IL-4 has no effect on p21-bound GDP/GTP. These results strongly suggest that ras p21 acts as a transducer of signals from IL-2, IL-3, and GM-CSF, but not from IL-4.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.