ArticleThe American journal of clinical nutrition2007
Dietary soy and tea combinations for prevention of breast and prostate cancers by targeting metabolic syndrome elements in mice.
Article in The American journal of clinical nutrition, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 43 citations in OpenAlex.
- Green tea minimally affects biomarkers of inflammation in obese subjects with metabolic syndrome.Nutrition (Burbank, Los Angeles County, Calif.) · 2011Trial
- Serum IGF-1 concentrations change with soy and seaweed supplements in healthy postmenopausal American women.Nutrition and cancer · 2011Trial
- 10-Hydroxy Decanoic Acid and Zinc Oxide Nanoparticles Retrieve Nrf2/HO-1 and Caspase-3/Bax/Bcl-2 Signaling in Lead-Induced Testicular Toxicity.Biological trace element research · 2025Article
- Combination of 10-hydroxy-decanoic acid and ZnO nanoparticles abrogates lead acetate-induced nephrotoxicity in rats: targeting oxidative stress and inflammatory signalling.BMC pharmacology & toxicology · 2025Article
- Causal associations between atrial fibrillation and breast cancer: A bidirectional Mendelian randomization analysis.Cancer medicine · 2024Article
- The Therapeutic Potential of Two Egyptian Plant Extracts for Mitigating Dexamethasone-Induced Osteoporosis in Rats: Nrf2/HO-1 and RANK/RANKL/OPG Signals.Antioxidants (Basel, Switzerland) · 2024Article
- Long-Term Consumption of Green Tea Can Reduce the Degree of Depression in Postmenopausal Women by Increasing Estradiol.Nutrients · 2023Article
- The Synergetic Effect of EgyptianAntioxidants (Basel, Switzerland) · 2022Article
- Synergistic protective effect of Beta vulgaris with meso-2,3-dimercaptosuccinic acid against lead-induced neurotoxicity in male rats.Scientific reports · 2021Article
- Relevance of the Isoflavone Absorption and Testicular Function: A Systematic Review of Preclinical Evidence.Evidence-based complementary and alternative medicine : eCAM · 2021Review
- The Multitarget Activity of Natural Extracts on Cancer: Synergy and Xenohormesis.Medicines (Basel, Switzerland) · 2018Review
- The ameliorating effect of the combined extract from GreekRSC advances · 2018Article
- Exploring the potential of black tea based flavonoids against hyperlipidemia related disorders.Lipids in health and disease · 2018Article
- Aqueous and ethanolic extracts of welsh onion, Allium fistulosum, attenuate high-fat diet-induced obesity.BMC complementary and alternative medicine · 2018Article
- Metabolic profile response to administration of epigallocatechin-3-gallate in high-fat-fed mice.Diabetology & metabolic syndrome · 2014Article
- Article
- Cancer prevention by targeting angiogenesis.Nature reviews. Clinical oncology · 2012Review
- Cancer complementary and alternative medicine research at the US National Cancer Institute.Chinese journal of integrative medicine · 2012Article
- Lunasin-aspirin combination against NIH/3T3 cells transformation induced by chemical carcinogens.Plant foods for human nutrition (Dordrecht, Netherlands) · 2011Article
- Symposium introduction: metabolic syndrome and the onset of cancer.The American journal of clinical nutrition · 2007Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe prevalence of metabolic syndrome is high and is increasing in parallel with increasing incidences of breast and prostate cancers. The combination of soy with tea was shown to have synergistic effects on preventing breast and prostate tumors, but the effects of soy and tea combinations on metabolic syndrome-related elements have not been investigated.
objectiveWe aimed to determine the effects of soy and tea components, alone and in combination, on abdominal adipose mass and serum concentrations of adipokines, growth factors, and sex hormones in male and female mice.
designMale and female FVB/N mice were treated with soy, tea components, or both. Food intake and body weight were monitored weekly. At the end of the experiment, abdominal white adipose tissue was weighed, and serum concentrations of biomarkers were measured.
resultsWhole teas, but not the tea polyphenol extracts, significantly reduced abdominal white adipose tissue by 43-60% in female mice and by 65-70% in male mice. The combination of soy phytochemical concentrate and green tea reduced serum insulin-like growth factor-I concentrations in both male and female mice in a synergistic manner. The soy phytochemical concentrate and tea combinations reduced serum estrogen concentrations in female mice in a synergistic manner. Soy phytochemical concentrate and teas also significantly reduced serum leptin concentrations in both male and female mice and testosterone concentrations in male mice.
conclusionFurther research is warranted to investigate whether soy and tea combinations may prevent breast or prostate cancer in a synergistic manner in part by alleviating metabolic disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.