ArticleThe Journal of comparative neurology2008
cpg15 and cpg15-2 constitute a family of activity-regulated ligands expressed differentially in the nervous system to promote neurite growth and neuronal survival.
Article in The Journal of comparative neurology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 49 citations in OpenAlex.
- Article
- Integrated Proteomics to Understand the Role of Neuritin (NRN1) as a Mediator of Cognitive Resilience to Alzheimer's Disease.Molecular & cellular proteomics : MCP · 2023Article
- LGI1 governs neuritin-mediated resilience to chronic stress.Neurobiology of stress · 2021Article
- Expanding the phenotype associated with interstitial 6p25.1p24.3 microdeletion: a new case and review of the literature.Journal of genetics · 2021Review
- miR‑199a decreases Neuritin expression involved in the development of Alzheimer's disease in APP/PS1 mice.International journal of molecular medicine · 2020Article
- Adaptive Fisher method detects dense and sparse signals in association analysis of SNV sets.BMC medical genomics · 2020Article
- Functions and the related signaling pathways of the neurotrophic factor neuritin.Acta pharmacologica Sinica · 2018Review
- Axonal G3BP1 stress granule protein limits axonal mRNA translation and nerve regeneration.Nature communications · 2018Article
- Neuritin Attenuates Neuronal Apoptosis Mediated by Endoplasmic Reticulum Stress In Vitro.Neurochemical research · 2018Article
- Article
- Maternal deprivation alters expression of neural maturation gene tbr1 in the amygdala paralaminar nucleus in infant female macaques.Developmental psychobiology · 2017Article
- Neuritin Mediates Activity-Dependent Axonal Branch Formation in Part via FGF Signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Neuritin reverses deficits in murine novel object associative recognition memory caused by exposure to extremely low-frequency (50 Hz) electromagnetic fields.Scientific reports · 2015Article
- Neuritin 1 promotes retinal ganglion cell survival and axonal regeneration following optic nerve crush.Cell death & disease · 2015Article
- Neuritin can normalize neural deficits of Alzheimer's disease.Cell death & disease · 2014Article
- Optic nerve crush induces spatial and temporal gene expression patterns in retina and optic nerve of BALB/cJ mice.Molecular neurodegeneration · 2014Article
- Aberrant development and plasticity of excitatory visual cortical networks in the absence of cpg15.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Neuritin attenuates cognitive function impairments in tg2576 mouse model of Alzheimer's disease.PloS one · 2014Article
- Axonal localization of neuritin/CPG15 mRNA in neuronal populations through distinct 5' and 3' UTR elements.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Many ligands that affect nervous system development are members of gene families that function together to coordinate the assembly of complex neural circuits. cpg15/neuritin encodes an extracellular ligand that promotes neurite growth, neuronal survival, and synaptic maturation. Here we identify cpg15-2 as the only paralogue of cpg15 in the mouse and human genome. Both genes are expressed predominantly in the nervous system, where their expression is regulated by activity. cpg15-2 expression increases by more than twofold in response to kainate-induced seizures and nearly fourfold in the visual cortex in response to 24 hours of light exposure following dark adaptation. cpg15 and cpg15-2 diverge in their spatial and temporal expression profiles. cpg15-2 mRNA is most abundant in the retina and the olfactory bulb, as opposed to the cerebral cortex and the hippocampus for cpg15. In the retina, they differ in their cell-type specificity. cpg15 is expressed in retinal ganglion cells, whereas cpg15-2 is predominantly in bipolar cells. Developmentally, onset of cpg15-2 expression is delayed compared with cpg15 expression. CPG15-2 is glycosylphosphatidylinositol (GPI) anchored to the cell membrane and, like CPG15, can be released in a soluble-secreted form, but with lower efficiency. CPG15 and CPG15-2 were found to form homodimers and heterodimers with each other. In hippocampal explants and dissociated cultures, CPG15 and CPG15-2 promote neurite growth and neuronal survival with similar efficacy. Our findings suggest that CPG15 and CPG15-2 perform similar cellular functions but may play distinct roles in vivo through their cell-type- and tissue-specific transcriptional regulation.
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