Evidence map›Paper›PMID 18264753›Full record

ReviewAIDS and behavior2010

Population levels of psychological stress, herpesvirus reactivation and HIV.

Allison E Aiello, Amanda M Simanek, Sandro Galea

Abstract readReview
In one paragraph

Review in AIDS and behavior, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 42 citations in OpenAlex.

  1. Trial
  2. Article
  3. Stress-responsive biomarkers and sexual behaviors among young women in rural South Africa.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2025
    Article
  4. Article
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  7. Social history and exposure to pathogen signals modulate social status effects on gene regulation in rhesus macaques.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
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  9. Review
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  13. Review
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  15. Neighborhoods and infectious disease risk: acquisition of chlamydia during the transition to young adulthood.Journal of urban health : bulletin of the New York Academy of Medicine · 2014
    Observational
  16. Article
  17. Neighborhood disadvantage and changes in condom use among African American adolescents.Journal of urban health : bulletin of the New York Academy of Medicine · 2011
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Allison E AielloDepartment of Epidemiology, Center for Social Epidemiology & Population Health, University of Michigan-School of Public Health, 3659 SPH Tower, 109 Observatory, Ann Arbor, MI 48109-2029, USA. aielloa@umich.edu
Amanda M Simanek
Sandro Galea
University of Michigan–Ann Arbor · US

Funding

MI Interdisciplinary Ctr-Social Inequality, Mind &BodyR24HD047861 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KAPLAN, GEORGE A. · 2004 to 2008
$5.0M
NICHD NIH HHS R24 HD047861
6 · The paper itself

Abstract

Nearly 40,000 Americans are newly infected with Human Immunodeficiency Virus (HIV) each year. Recently, studies have demonstrated associations between group-level characteristics and the prevalence and incidence of HIV/Acquired Immune Deficiency Syndrome (AIDS) and other sexually transmitted diseases. Two mechanisms previously posited to explain these associations are neighborhood effects on risk behaviors and social or institutional policies. In this paper, we hypothesize that adversity at the population level, such as neighborhood poverty, also influences HIV risk through stress-mediated aberrations in immunological susceptibility by reviewing existing data examining each of these pathways. In particular, we review the evidence showing that: (1) Neighborhood ecologic stressors influence neighborhood- and individual-levels of mental health, psychosocial stress, and HIV/AIDS risk, (2) Individual-level psychosocial stressors influence progression from HIV to AIDS through stress-related hormonal changes, and (3) Individual-level psychosocial stressors influence HIV acquisition via stress-related reactivation of latent herpesviruses, specifically EBV and HSV-2. Our review indicates that further studies are needed to examine the joint pathways linking neighborhood-level sources of psychosocial stress, stress-related reactivation of HSV-2 and EBV, and increased acquisition rates of HIV. We suggest using a multi-level framework for targeting HIV prevention efforts that address not only behavioral risk factors, but structural, political, and institutional factors associated with neighborhood disadvantage, levels of psychosocial stress, and prevention or treatment of HSV-2 and EBV.

Indexed as

Residence CharacteristicsVirus ActivationEpstein-Barr Virus InfectionsHerpes GenitalisHerpesvirus 2, HumanHerpesvirus 4, HumanHIV InfectionsHumansRisk FactorsStress, Psychological

Identifiers

PMID18264753
PMCPMC4156100
OpenAlexW2063258533

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.