Evidence map›Paper›PMID 18264751›Full record

ReviewAIDS and behavior2009

The role of host genetics in the susceptibility for HIV-associated neurocognitive disorders.

Andrew J Levine, Elyse J Singer, Paul Shapshak

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in AIDS and behavior, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Genetic, transcriptomic, and epigenetic studies of HIV-associated neurocognitive disorder.Journal of acquired immune deficiency syndromes (1999) · 2014
    Review
  7. Genome-wide association study of neurocognitive impairment and dementia in HIV-infected adults.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2012
    Article
  8. Article
  9. Article
  10. Review
  11. Editorial neuroAIDS review.AIDS (London, England) · 2011
    Review
  12. Article
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Andrew J LevineNational Neurological AIDS Bank, Department of Neurology, University of California Los Angeles - David Geffen School of Medicine, 11645 Wilshire Blvd., Suite 770, Los Angeles, CA, 90025, USA. ajlevine@mednet.ucla.edu
Elyse J Singer
Paul Shapshak
University of California, Los Angeles · USUniversity of South Florida · US

Funding

YALE CENTER FOR THE: LEARNING &ATTENTIONP41RR013642 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BEARER, ELAINE L · 1998 to 2011
$21.9M
NATIONAL NEUROLOGICAL AIDS BANKU24MH100929 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SINGER, ELYSE J · 2013 to 2023
$12.5M
National Neurological AIDS Bank (NNAB)R24NS038841 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SINGER, ELYSE J · 1998 to 2007
$12.0M
National Neurological AIDS BankU01MH083500 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SINGER, ELYSE J · 2008 to 2012
$7.2M
COMMUNITY DEPOSIT AND REVIEW OF BIOCHEMICAL DATABASESR01GM056529 · NIGMS · WASHINGTON UNIVERSITY · PI KAZIC, TONI · 1997 to 2006
$2.4M
HIV INFECTION POTENTIAL /IDU-RELATED INJECTION MATERIALSR01DA012580 · NIDA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI PAGE, JOHN BRYAN · 2000 to 2002
$1.2M
GENE EXPRESSION IN HIV ASSOCIATED DEMENTIA BRAINR21DA014533 · NIDA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI SHAPSHAK, PAUL · 2001 to 2004
$795k
NCRR NIH HHS P41 RR013642NIDA NIH HHS DA12580NIDA NIH HHS DA14533NIDA NIH HHS R01 DA012580NIDA NIH HHS R21 DA014533NIGMS NIH HHS GM056529NIGMS NIH HHS R01 GM056529NIMH NIH HHS U01 MH083500NIMH NIH HHS U24 MH100929NINDS NIH HHS NS-38841NINDS NIH HHS R24 NS038841
6 · The paper itself

Abstract

Despite progress in the treatment of the Human Immunodeficiency virus (HIV), there continues to be a high prevalence of infected individuals who develop neurocognitive deficits and disorders. Our understanding of the potential cause of HIV-associated neurocognitive disorders (HAND) continues to develop on many fronts. Among them is the study of host genetics. Here, we review the most current information regarding the association between host genetics and risk for HIV infection, AIDS, and HAND. We focus on the role of dopamine dysfunction in the etiology of HAND, and propose a number of genetic polymorphisms within genes related to dopaminergic functioning and other neurobiological factors that may confer vulnerability or protection against HAND.

Indexed as

AIDS Dementia ComplexAntiretroviral Therapy, Highly ActiveApolipoproteins EBrain-Derived Neurotrophic FactorCatechol O-MethyltransferaseCognition DisordersDopamine and cAMP-Regulated Phosphoprotein 32Dopamine Plasma Membrane Transport ProteinsGenetic Predisposition to DiseaseHIV InfectionsHumansPolymorphism, GeneticPrevalenceReceptors, DopamineApolipoproteins EBrain-Derived Neurotrophic FactorCatechol O-MethyltransferaseDopamine and cAMP-Regulated Phosphoprotein 32Dopamine Plasma Membrane Transport ProteinsPPP1R1B protein, humanReceptors, DopamineSLC6A3 protein, human

Identifiers

PMID18264751
PMCPMC4433163
OpenAlexW2045934707

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.