ReviewJournal of clinical immunology2008
Primary immune deficiency disorders presenting as autoimmune diseases: IPEX and APECED.
Review in Journal of clinical immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 113 citations in OpenAlex.
- "IL-2 immunotherapy for targeting regulatory T cells in autoimmunity".Genes and immunity · 2023Review
- Molecular and clinical characterization of autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy syndrome (APECED) in Iranian non-Jewish patients: report of two novel AIRE gene pathogenic variants.Orphanet journal of rare diseases · 2022Article
- Effects of interleukin-2 in immunostimulation and immunosuppression.The Journal of experimental medicine · 2020Review
- IPEX Syndrome with Normal FOXP3 Protein Expression in Treg Cells in an Infant Presenting with Intractable Diarrhea as a Single Symptom.Case reports in immunology · 2020Article
- Primary immunodeficiency diseases in lung disease: warning signs, diagnosis and management.Respiratory research · 2018Review
- Probiotics in Disease Prevention and Treatment.Journal of clinical pharmacology · 2018Article
- Cutting Edge: Low-Affinity TCRs Support Regulatory T Cell Function in Autoimmunity.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Cutting Edge: Dual TCRα Expression Poses an Autoimmune Hazard by Limiting Regulatory T Cell Generation.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Humoral Immunodeficiency with Hypotonia, Feeding Difficulties, Enteropathy, and Mild Eczema Caused by a ClassicalFrontiers in pediatrics · 2017Article
- Rheumatologic manifestations of primary immunodeficiency diseases.Clinical rheumatology · 2016Review
- Mucosal Regulatory T Cells and T Helper 17 Cells in HIV-Associated Immune Activation.Frontiers in immunology · 2016Article
- The diagnostic challenge of very early-onset enterocolitis in an infant with XIAP deficiency.BMC pediatrics · 2015Article
- Primary immunodeficiency update: Part I. Syndromes associated with eczematous dermatitis.Journal of the American Academy of Dermatology · 2015Review
- The promise of low-dose interleukin-2 therapy for autoimmune and inflammatory diseases.Nature reviews. Immunology · 2015Review
- Translating Treg Therapy in Humanized Mice.Frontiers in immunology · 2015Review
- Missing Cells: Pathophysiology, Diagnosis, and Management of (Pan)Cytopenia in Childhood.Frontiers in pediatrics · 2015Review
- Lactobacillus reuteri DSM 17938 differentially modulates effector memory T cells and Foxp3+ regulatory T cells in a mouse model of necrotizing enterocolitis.American journal of physiology. Gastrointestinal and liver physiology · 2014Article
- Laboratory diagnosis of primary immunodeficiencies.Clinical reviews in allergy & immunology · 2014Review
- Clinical Case of Immune Dysregulation, Polyendocrinopaty, Enteropathy, X-Linked (IPEX) Syndrome with Severe Immune Deficiency and Late Onset of Endocrinopathy and Enteropathy.Case reports in medicine · 2014Article
- Tolerance and autoimmunity in primary immunodeficiency disease: a comprehensive review.Clinical reviews in allergy & immunology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundSeveral primary immune deficiency disorders are associated with autoimmunity and malignancy, suggesting a state of immune dysregulation. The concept of immune dysregulation as a direct cause of autoimmunity in primary immune deficiency disorders (PIDDs) has been strengthened by the recent discovery of distinct clinical entities linked to single-gene defects resulting in multiple autoimmune phenomena including immune dysregulation, polyendocrinopathy, enteropathy and X-linked (IPEX) syndrome, and autoimmune polyendocrinopathy, candidiasis and ectodermal dystrophy (APECED) syndrome.
conclusionReviewing recent advances in our understanding of the small subgroup of PIDD patients with defined causes for autoimmunity may lead to the development of more effective treatment strategies for idiopathic human autoimmune diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.