ArticleJournal of cancer research and clinical oncology2008
Colorectal cancer occurs earlier in those exposed to tobacco smoke: implications for screening.
Article in Journal of cancer research and clinical oncology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- Article
- Association of a Healthy Lifestyle with All-Cause, Cause-Specific Mortality and Incident Cancer among Individuals with Metabolic Syndrome: A Prospective Cohort Study in UK Biobank.International journal of environmental research and public health · 2022Article
- Factors associated with positive predictive value of preliminary screening in a two-step screening strategy for colorectal neoplasms in China.Discover oncology · 2022Article
- Genetic risk, incident colorectal cancer, and the benefits of adhering to a healthy lifestyle: A prospective study using data from UK Biobank and FinnGen.Frontiers in oncology · 2022Article
- Cancer Research Trend Analysis Based on Fusion Feature Representation.Entropy (Basel, Switzerland) · 2021Article
- Tea polyphenols and their chemopreventive and therapeutic effects on colorectal cancer.World journal of gastroenterology · 2020Review
- Colorectal Cancer in the Adolescent and Young Adult Population.JCO oncology practice · 2020Article
- Characterization of cancer stem cells from different grades of human colorectal cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Do recent epidemiologic observations impact who and how we should screen for CRC?Digestive diseases and sciences · 2015Review
- Expression and prognostic value of tumor stem cell markers ALDH1 and CD133 in colorectal carcinoma.Oncology letters · 2014Article
- Alcohol and tobacco lower the age of presentation in sporadic pancreatic cancer in a dose-dependent manner: a multicenter study.The American journal of gastroenterology · 2012Article
- The effect of cigarette smoking on cancer treatment-related side effects.The oncologist · 2011Article
- The effect of secondhand smoke exposure on the association between active cigarette smoking and colorectal cancer.Cancer causes & control : CCC · 2010Article
- Risk factors for colorectal cancer in patients with multiple serrated polyps: a cross-sectional case series from genetics clinics.PloS one · 2010Article
- Phenotypic diversity in patients with multiple serrated polyps: a genetics clinic study.International journal of colorectal disease · 2010Article
- Health and lifestyle behaviors among persons at risk of Lynch syndrome.Cancer causes & control : CCC · 2010Article
- Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundColorectal cancer (CRC) is the third most common cancer in the USA. While various lifestyle factors have been shown to alter the risk for colorectal cancer, recommendations for the early detection of CRC are based only on age and family history.
methodsThis case-only study examined the age at diagnosis of colorectal cancer in subjects exposed to tobacco smoke. Subjects included all patients who attended RPCI between 1957 and 1997, diagnosed with colorectal cancer, and completed an epidemiologic questionnaire. Adjusted linear regression models were calculated for the various smoking exposures.
resultsOf the 3,540 cases of colorectal cancer, current smokers demonstrated the youngest age of CRC onset (never: 64.2 vs. current: 57.4, P < 0.001) compared to never smokers, followed by recent former smokers. Among never smokers, individuals with past second-hand smoke exposure were diagnosed at a significantly younger age compared to the unexposed.
conclusionThis study found that individuals with heavy, long-term tobacco smoke exposure were significantly younger at the time of CRC diagnosis compared to lifelong never smokers. The implication of this finding is that screening for colorectal cancer, which is recommended to begin at age 50 years for persons at average risk should be initiated 5-10 years earlier for persons with a significant lifetime history of exposure to tobacco smoke.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.