ArticleJournal of cancer research and clinical oncology2008
Single nucleotide polymorphism D1853N of the ATM gene may alter the risk for breast cancer.
Article in Journal of cancer research and clinical oncology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 6 of them syntheses that pooled it.
What it found
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Who cites it
27 citing papers in PubMed, 6 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Polymorphism rs1801516 (G > A) in theThe Journal of international medical research · 2020Pooled it
- Association between ATM rs1801516 polymorphism and cancer susceptibility: a meta-analysis involving 12,879 cases and 18,054 controls.BMC cancer · 2018Pooled it
- Pooled it
- Association between ATM 5557G>A polymorphism and breast cancer risk: a meta-analysis.Molecular biology reports · 2012Pooled it
- The association between ATM D1853N polymorphism and breast cancer susceptibility: a meta-analysis.Journal of experimental & clinical cancer research : CR · 2010Pooled it
- Association between a germline OCA2 polymorphism at chromosome 15q13.1 and estrogen receptor-negative breast cancer survival.Journal of the National Cancer Institute · 2010Pooled it
- Polymorphisms in the RANK/RANKL genes and their effect on bone specific prognosis in breast cancer patients.BioMed research international · 2014Trial
- Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array.British journal of cancer · 2009Trial
- RANK and RANKL Expression in Tumors of Patients with Early Breast Cancer.Geburtshilfe und Frauenheilkunde · 2024Article
- Clinico-genomic findings, molecular docking, and mutational spectrum in an understudied population with breast cancer patients from KP, Pakistan.Frontiers in genetics · 2024Article
- ATM in breast and brain tumors: a comprehensive review.Cancer biology & medicine · 2018Article
- Genetic determinants of sporadic breast cancer in Sri Lankan women.BMC cancer · 2018Article
- Endometriosis as a risk factor for ovarian or endometrial cancer - results of a hospital-based case-control study.BMC cancer · 2015Article
- Common variants at 9q22.33, 14q13.3, and ATM loci, and risk of differentiated thyroid cancer in the French Polynesian population.PloS one · 2015Article
- CYP2B6*6 is associated with increased breast cancer risk.International journal of cancer · 2014Article
- Molecular defects in Moroccan patients with ataxia-telangiectasia.Neuromolecular medicine · 2013Article
- The UGT1A6_19_GG genotype is a breast cancer risk factor.Frontiers in genetics · 2013Article
- Overexpression of SERBP1 (Plasminogen activator inhibitor 1 RNA binding protein) in human breast cancer is correlated with favourable prognosis.BMC cancer · 2012Article
- Variations of the ataxia telangiectasia mutated gene in patients with chronic lymphocytic leukemia lack substantial impact on progression-free survival and overall survival: a Cancer and Leukemia Group B study.Leukemia & lymphoma · 2012Article
- Percent Mammographic Density and Dense Area as Risk Factors for Breast Cancer.Geburtshilfe und Frauenheilkunde · 2012Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeVarious ATM (ataxia telangiectasia-mutated) mutations and polymorphisms have been reported to be associated with an increased breast cancer risk. Recent studies have produced contradictory results regarding the association between ATM genetic variants and breast cancer risk. MATERIALS AND
methodsThe common ATM polymorphism 5557G>A (p.D1853N) (rs1801516), previously suggested to be associated with bilateral breast cancer, was analyzed using real-time PCR in 514 unselected patients with breast cancer and 511 age-matched healthy control individuals. DNA was obtained from peripheral blood draw.
resultsThe ATM genotype was weakly associated with the risk for breast cancer (P = 0.04 for the overall test). The odds ratio for women with a heterozygous genotype was 0.70 (95% CI, 0.52-0.94) and for the homozygous variant 0.63 (95% CI, 0.27-1.49). Disease-free survival and overall survival showed no significant association with specific genotypes.
conclusionsThe results of this study might suggest a minor association between polymorphism 5557G>A and a reduced risk of breast cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.