ReviewIntensive care medicine2008
Effects of mechanical ventilation on the extracellular matrix.
Review in Intensive care medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 1 synthesis or guideline pooled it, 119 citations in OpenAlex.
- Protective mechanical ventilation in the non-injured lung: review and meta-analysis.Critical care (London, England) · 2014Pooled it
- Trial
- Is volume and leak monitoring feasible during nasopharyngeal continuous positive airway pressure in neonates?Intensive care medicine · 2009Trial
- The janus-faced extracellular matrix remodeling in acute lung injury: a gatekeeper of macrophage localization and phenotype.Science China. Life sciences · 2026Article
- Role of Tidal Volume on Ventilator-Induced Lung Injury Under Heterogeneous Immunological Capabilities: A Mathematical Model Study.Life (Basel, Switzerland) · 2025Article
- Complement activation and lung injury in Japanese patients with COVID-19: a prospective observational study.Scientific reports · 2024Observational
- Repetitive invasive lung function maneuvers do not accentuate experimental fibrosis in mice.Scientific reports · 2024Article
- Effects of mechanical ventilation on the interstitial extracellular matrix in healthy lungs and lungs affected by acute respiratory distress syndrome: a narrative review.Critical care (London, England) · 2024Review
- Airflow-Related Shear Stress: The Main Cause of VILI or not?Tanaffos · 2024Article
- The correlation between serum levels of laminin, type IV collagen, type III procollagen N-terminal peptide and hyaluronic acid with the progression of post-COVID-19 pulmonary fibrosis.Frontiers in cell and developmental biology · 2024Article
- High driving pressure ventilation induces pulmonary hypertension in a rabbit model of acute lung injury.Journal of intensive care · 2023Article
- Post-COVID-19 Pulmonary Fibrosis: Facts-Challenges and Futures: A Narrative Review.Pulmonary therapy · 2023Review
- Ventilator-Induced Lung Injury as a Dynamic Balance Between Epithelial Cell Damage and Recovery.Annals of biomedical engineering · 2023Article
- Decellularized Avian Cartilage, a Promising Alternative for Human Cartilage Tissue Regeneration.Materials (Basel, Switzerland) · 2022Article
- From ARDS to pulmonary fibrosis: the next phase of the COVID-19 pandemic?Translational research : the journal of laboratory and clinical medicine · 2022Review
- A tunable physiomimetic stretch system evaluated with precision cut lung slices and recellularized human lung scaffolds.Frontiers in bioengineering and biotechnology · 2022Article
- Computed Tomography Assessment of Tidal Lung Overinflation in Domestic Cats Undergoing Pressure-Controlled Mechanical Ventilation During General Anesthesia.Frontiers in veterinary science · 2022Article
- Recovering from a pandemic: pulmonary fibrosis after SARS-CoV-2 infection.European respiratory review : an official journal of the European Respiratory Society · 2021Review
- Procollagen I and III as Prognostic Markers in Patients Treated with Extracorporeal Membrane Oxygenation: A Prospective Observational Study.Journal of clinical medicine · 2021Article
- [Reinterpreting the ventilator-induced lung injury from the prospective of mechanical power].Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns · 2021Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The extracellular matrix (ECM) plays an important role in the biomechanical behaviour of the lung parenchyma. The ECM is composed of a three-dimensional fibre mesh filled with different macromolecules, including the glycosaminoglycans and the proteoglycans, which have important functions in many lung pathophysiological processes: (1) regulating the hydration and water homeostasis, (2) maintaining the structure and function, (3) modulating the inflammatory response, and (4) influencing tissue repair and remodelling. Ventilator-induced lung injury is the result of a complex interplay among various mechanical forces acting on lung structures such as the epithelial and endothelial cells, the extracellular matrix, and the peripheral airways during mechanical ventilation. Although excellent reviews have synthesized our current knowledge of the role of repeated cyclic stretch and high tidal volume ventilation on alveolar and endothelial cells, few have addressed the effects of mechanical ventilation on the ECM. The present review focused on the organization of the ECM, mechanotransduction and ECM interactions, and the effects of mechanical ventilation on the ECM. The study of the ECM may be useful to improve our understanding of the pathophysiology of lung damage induced by mechanical ventilation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.