ReviewJournal of applied genetics2008
Aberrant epigenetic patterns in the etiology of gastrointestinal cancers.
Review in Journal of applied genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Forkhead box E1, frequently downregulted by promoter methylation, inhibits colorectal cancer cell growth and migration.Cancer cell international · 2024Article
- RANDOMIZE: A Web Server for Data Randomization.Archives of proteomics and bioinformatics · 2020Article
- Drug resistance induces the upregulation of HBiochemical pharmacology · 2018Article
- The novel colorectal cancer biomarkers CDO1, ZSCAN18 and ZNF331 are frequently methylated across gastrointestinal cancers.International journal of cancer · 2015Article
- JNK confers 5-fluorouracil resistance in p53-deficient and mutant p53-expressing colon cancer cells by inducing survival autophagy.Scientific reports · 2014Article
- Inhibition of TMEM16A expression suppresses growth and invasion in human colorectal cancer cells.PloS one · 2014Article
- Stratified randomization controls better for batch effects in 450K methylation analysis: a cautionary tale.Frontiers in genetics · 2014Article
- Article
- The blues of P(16)INK(4a): aberrant promoter methylation and association with colorectal cancer in the Kashmir valley.Molecular medicine reports · 2012Article
- Article
- Detection of viral DNA sequences in sporadic colorectal cancers in relation to CpG island methylation and methylator phenotype.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2011Article
- Analysis of molecular aberrations of Wnt pathway gladiators in colorectal cancer in the Kashmiri population.Human genomics · 2011Article
- Oridonin induces apoptosis and senescence in colorectal cancer cells by increasing histone hyperacetylation and regulation of p16, p21, p27 and c-myc.BMC cancer · 2010Article
- Article
- Methylated DNA immunoprecipitation.Journal of visualized experiments : JoVE · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A body of evidence accumulated over the past decade suggests that epigenetic mechanisms play an essential role in maintaining important cellular functions. Changes in epigenetic patterns (mainly DNA hyper- and hypomethylation and, more recently, histone modifications) may contribute to the development of cancer. Aberrant epigenetic events expand thorough tumor progression from the earliest to latest stages, therefore they can serve as convenient markers for detection and prognosis of cancer. The potential reversibility of epigenetic states in the tumor cell is an attractive target for cancer therapy. Much of our current knowledge on epigenetic alternations in cancer comes from studies on gastrointestinal malignancies, mainly on colorectal cancer, which currently serves as a model for epigenetic tumorigenesis. This review summarizes the current knowledge of epigenetic changes in gastrointestinal cancers and how this relates directly to disease progression and prognosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.