ArticleJournal of bacteriology2008
Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.
Article in Journal of bacteriology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 57 citations in OpenAlex.
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- Complete genome sequence of and proposal of Thermofilum uzonense sp. nov. a novel hyperthermophilic crenarchaeon and emended description of the genus Thermofilum.Standards in genomic sciences · 2015Article
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- Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.Extremophiles : life under extreme conditions · 2014Article
- Analysis of the transcriptional regulator GlpR, promoter elements, and posttranscriptional processing involved in fructose-induced activation of the phosphoenolpyruvate-dependent sugar phosphotransferase system in Haloferax mediterranei.Applied and environmental microbiology · 2014Article
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- Comparative analysis of amino acid sequences from mesophiles and thermophiles in respective of carbon-nitrogen hydrolase family.3 Biotech · 2013Article
- Complete Genomic Sequence of "Thermofilum adornatus" Strain 1910bT, a Hyperthermophilic Anaerobic Organotrophic Crenarchaeon.Genome announcements · 2013Article
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- Association of novel domain in active site of archaic hyperthermophilic maltogenic amylase from Staphylothermus marinus.The Journal of biological chemistry · 2012Article
- SAFE Software and FED Database to Uncover Protein-Protein Interactions using Gene Fusion Analysis.Evolutionary bioinformatics online · 2012Article
- Purine biosynthesis in archaea: variations on a theme.Biology direct · 2011Article
- The complete genome sequence of Thermoproteus tenax: a physiologically versatile member of the Crenarchaeota.PloS one · 2011Article
- Multiple syntrophic interactions in a terephthalate-degrading methanogenic consortium.The ISME journal · 2011Article
- Enigmatic, ultrasmall, uncultivated Archaea.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
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Authors and funding
23 authors at 5 institutions in 1 country.
Funding
Abstract
We report the complete genome of Thermofilum pendens, a deeply branching, hyperthermophilic member of the order Thermoproteales in the archaeal kingdom Crenarchaeota. T. pendens is a sulfur-dependent, anaerobic heterotroph isolated from a solfatara in Iceland. It is an extracellular commensal, requiring an extract of Thermoproteus tenax for growth, and the genome sequence reveals that biosynthetic pathways for purines, most amino acids, and most cofactors are absent. In fact, T. pendens has fewer biosynthetic enzymes than obligate intracellular parasites, although it does not display other features that are common among obligate parasites and thus does not appear to be in the process of becoming a parasite. It appears that T. pendens has adapted to life in an environment rich in nutrients. T. pendens was known previously to utilize peptides as an energy source, but the genome revealed a substantial ability to grow on carbohydrates. T. pendens is the first crenarchaeote and only the second archaeon found to have a transporter of the phosphotransferase system. In addition to fermentation, T. pendens may obtain energy from sulfur reduction with hydrogen and formate as electron donors. It may also be capable of sulfur-independent growth on formate with formate hydrogen lyase. Additional novel features are the presence of a monomethylamine:corrinoid methyltransferase, the first time that this enzyme has been found outside the Methanosarcinales, and the presence of a presenilin-related protein. The predicted highly expressed proteins do not include proteins encoded by housekeeping genes and instead include ABC transporters for carbohydrates and peptides and clustered regularly interspaced short palindromic repeat-associated proteins.
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