ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2008
Calcium signalling in early embryos.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 66 citations in OpenAlex.
- Single-cell transcriptomic analysis reveals subtle fluctuations of oocyte cryopreservation on mouse early embryo development.Clinical and translational medicine · 2026Article
- Protease-mediated activation of Par2 elicits calcium waves during zebrafish egg activation and blastomere cleavage.PLoS biology · 2025Article
- Exploring Differentially Expressed Sperm miRNAs in Idiopathic Recurrent Pregnancy Loss and Their Association with Early Embryonic Development.Non-coding RNA · 2024Article
- Myo-inositol effect on pregnancy outcomes in infertile women undergoing in vitro fertilization/intracytoplasmic sperm injection: A double-blind RCT.International journal of reproductive biomedicine · 2022Article
- Fertilization, Oocyte Activation, Calcium Release and Epigenetic Remodelling: Lessons From Cancer Models.Frontiers in cell and developmental biology · 2022Article
- What happens after a blood meal? A transcriptome analysis of the main tissues involved in egg production in Rhodnius prolixus, an insect vector of Chagas disease.PLoS neglected tropical diseases · 2020Article
- Expressed proteins and activated pathways in conditioned embryo culture media from IVF patients are diverse according to infertility factors.JBRA assisted reproduction · 2019Article
- Ladder-Shaped Ion Channel Ligands: Current State of Knowledge.Marine drugs · 2017Review
- Comparative Analysis of Spontaneous and Stimulus-Evoked Calcium Transients in Proliferating and Differentiating Human Midbrain-Derived Stem Cells.Stem cells international · 2017Article
- The Cytoskeleton and Its Regulation by Calcium and Protons.Plant physiology · 2016Review
- Frequency-dependent mitochondrial Ca(2+) accumulation regulates ATP synthesis in pancreatic β cells.Pflugers Archiv : European journal of physiology · 2013Article
- Calcium and egg activation in Drosophila.Cell calcium · 2013Review
- Article
- Dynamic analysis of Ca²+ level during bovine oocytes maturation and early embryonic development.Journal of veterinary science · 2011Article
- Loss of manganese superoxide dismutase leads to abnormal growth and signal transduction in mouse embryonic fibroblasts.Free radical biology & medicine · 2010Article
- Article
- A new MAP kinase protein involved in estradiol-stimulated reproduction of the helminth parasite Taenia crassiceps.Journal of biomedicine & biotechnology · 2010Article
- Mitochondrial functions on oocytes and preimplantation embryos.Journal of Zhejiang University. Science. B · 2009Review
- Introduction. Calcium signals and developmental patterning.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 2 countries.
Funding
Abstract
The onset of development in most species studied is triggered by one of the largest and longest calcium transients known to us. It is the most studied and best understood aspect of the calcium signals that accompany and control development. Its properties and mechanisms demonstrate what embryos are capable of and thus how the less-understood calcium signals later in development may be generated. The downstream targets of the fertilization calcium signal have also been identified, providing some pointers to the probable targets of calcium signals further on in the process of development. In one species or another, the fertilization calcium signal involves all the known calcium-releasing second messengers and many of the known calcium-signalling mechanisms. These calcium signals also usually take the form of a propagating calcium wave or waves. Fertilization causes the cell cycle to resume, and therefore fertilization signals are cell-cycle signals. In some early embryonic cell cycles, calcium signals also control the progress through each cell cycle, controlling mitosis. Studies of these early embryonic calcium-signalling mechanisms provide a background to the calcium-signalling events discussed in the articles in this issue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.